Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1

DNA replication stress drives genome instability and cancer. Here, Ölmezer and colleagues show that the helicase activity of multifunctional enzyme Dna2 suppresses dead-end replication structures that impair chromosome segregation if not removed by Holliday junction resolvase Yen1 in yeast.

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Autores principales:	Gizem Ölmezer, Maryna Levikova, Dominique Klein, Benoît Falquet, Gabriele Alessandro Fontana, Petr Cejka, Ulrich Rass
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2367aeec710c456184e031a5d8069fa2
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spelling	oai:doaj.org-article:2367aeec710c456184e031a5d8069fa22021-12-02T15:34:55ZReplication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen110.1038/ncomms131572041-1723https://doaj.org/article/2367aeec710c456184e031a5d8069fa22016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13157https://doaj.org/toc/2041-1723DNA replication stress drives genome instability and cancer. Here, Ölmezer and colleagues show that the helicase activity of multifunctional enzyme Dna2 suppresses dead-end replication structures that impair chromosome segregation if not removed by Holliday junction resolvase Yen1 in yeast.Gizem ÖlmezerMaryna LevikovaDominique KleinBenoît FalquetGabriele Alessandro FontanaPetr CejkaUlrich RassNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gizem Ölmezer Maryna Levikova Dominique Klein Benoît Falquet Gabriele Alessandro Fontana Petr Cejka Ulrich Rass Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1
description	DNA replication stress drives genome instability and cancer. Here, Ölmezer and colleagues show that the helicase activity of multifunctional enzyme Dna2 suppresses dead-end replication structures that impair chromosome segregation if not removed by Holliday junction resolvase Yen1 in yeast.
format	article
author	Gizem Ölmezer Maryna Levikova Dominique Klein Benoît Falquet Gabriele Alessandro Fontana Petr Cejka Ulrich Rass
author_facet	Gizem Ölmezer Maryna Levikova Dominique Klein Benoît Falquet Gabriele Alessandro Fontana Petr Cejka Ulrich Rass
author_sort	Gizem Ölmezer
title	Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1
title_short	Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1
title_full	Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1
title_fullStr	Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1
title_full_unstemmed	Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1
title_sort	replication intermediates that escape dna2 activity are processed by holliday junction resolvase yen1
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2367aeec710c456184e031a5d8069fa2
work_keys_str_mv	AT gizemolmezer replicationintermediatesthatescapedna2activityareprocessedbyhollidayjunctionresolvaseyen1 AT marynalevikova replicationintermediatesthatescapedna2activityareprocessedbyhollidayjunctionresolvaseyen1 AT dominiqueklein replicationintermediatesthatescapedna2activityareprocessedbyhollidayjunctionresolvaseyen1 AT benoitfalquet replicationintermediatesthatescapedna2activityareprocessedbyhollidayjunctionresolvaseyen1 AT gabrielealessandrofontana replicationintermediatesthatescapedna2activityareprocessedbyhollidayjunctionresolvaseyen1 AT petrcejka replicationintermediatesthatescapedna2activityareprocessedbyhollidayjunctionresolvaseyen1 AT ulrichrass replicationintermediatesthatescapedna2activityareprocessedbyhollidayjunctionresolvaseyen1
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Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1

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