Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective

Zhaoping Wang,1 Xiaolin Ni,1,2 Li Zhang,1 Liang Sun,1 Xiaoquan Zhu,1 Qi Zhou,1 Ze Yang,1 Huiping Yuan1 1The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Graduate School of Peking Union Medical College, Chinese Aca...

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Autores principales:	Wang Z, Ni X, Zhang L, Sun L, Zhu X, Zhou Q, Yang Z, Yuan H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	t2dm tlrs tlr4 inflammation tlr4 treatment. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/2367cb607f0a4fa194ea922ca38091ab
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spelling	oai:doaj.org-article:2367cb607f0a4fa194ea922ca38091ab2021-12-02T12:58:46ZToll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective1178-7007https://doaj.org/article/2367cb607f0a4fa194ea922ca38091ab2020-11-01T00:00:00Zhttps://www.dovepress.com/toll-like-receptor-4-and-inflammatory-micro-environment-of-pancreatic--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Zhaoping Wang,1 Xiaolin Ni,1,2 Li Zhang,1 Liang Sun,1 Xiaoquan Zhu,1 Qi Zhou,1 Ze Yang,1 Huiping Yuan1 1The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Huiping YuanThe MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Dongdan DaHua Road 1#, Beijing 100730, People’s Republic of ChinaTel +86-10-58115043Fax +86-10-65237929Email yuanhuiping@126.comAbstract: Patients with type-2 diabetes mellitus (T2DM) display chronic low-grade inflammation induced by activation of the innate immune system. Toll-like receptor (TLR)4 is a pattern recognition receptor that plays a vital part in activation of the innate immune system. Results from animal and computer-simulation studies have demonstrated that targeting TLR4 to block the TLR4-nuclear factor-kappa B (NF-κB) pathway reduces the inflammatory response and complications associated with T2DM. Therefore, TLR4-targeted therapy has broad prospects. Here, we reviewed the role of TLR4 in inflammation during chronic hyperglycemia in T2DM and its therapeutic prospects.Keywords: T2DM, TLRS, TLR4, inflammation, TLR4 treatmentWang ZNi XZhang LSun LZhu XZhou QYang ZYuan HDove Medical Pressarticlet2dmtlrstlr4inflammationtlr4 treatment.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4261-4272 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	t2dm tlrs tlr4 inflammation tlr4 treatment. Specialties of internal medicine RC581-951
spellingShingle	t2dm tlrs tlr4 inflammation tlr4 treatment. Specialties of internal medicine RC581-951 Wang Z Ni X Zhang L Sun L Zhu X Zhou Q Yang Z Yuan H Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
description	Zhaoping Wang,1 Xiaolin Ni,1,2 Li Zhang,1 Liang Sun,1 Xiaoquan Zhu,1 Qi Zhou,1 Ze Yang,1 Huiping Yuan1 1The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Huiping YuanThe MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Dongdan DaHua Road 1#, Beijing 100730, People’s Republic of ChinaTel +86-10-58115043Fax +86-10-65237929Email yuanhuiping@126.comAbstract: Patients with type-2 diabetes mellitus (T2DM) display chronic low-grade inflammation induced by activation of the innate immune system. Toll-like receptor (TLR)4 is a pattern recognition receptor that plays a vital part in activation of the innate immune system. Results from animal and computer-simulation studies have demonstrated that targeting TLR4 to block the TLR4-nuclear factor-kappa B (NF-κB) pathway reduces the inflammatory response and complications associated with T2DM. Therefore, TLR4-targeted therapy has broad prospects. Here, we reviewed the role of TLR4 in inflammation during chronic hyperglycemia in T2DM and its therapeutic prospects.Keywords: T2DM, TLRS, TLR4, inflammation, TLR4 treatment
format	article
author	Wang Z Ni X Zhang L Sun L Zhu X Zhou Q Yang Z Yuan H
author_facet	Wang Z Ni X Zhang L Sun L Zhu X Zhou Q Yang Z Yuan H
author_sort	Wang Z
title	Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title_short	Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title_full	Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title_fullStr	Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title_full_unstemmed	Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title_sort	toll-like receptor 4 and inflammatory micro-environment of pancreatic islets in type-2 diabetes mellitus: a therapeutic perspective
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2367cb607f0a4fa194ea922ca38091ab
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Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective

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