Epithelial tension in the second heart field promotes mouse heart tube elongation

Epithelial tension in the second heart field promotes mouse heart tube elongation

Epithelial progenitor cell growth in the second heart field contributes to heart morphogenesis but how this is regulated at the tissue level is unclear. Here, the authors show that cell elongation, polarized actomyosin and nuclear YAP/TAZ drive epithelial growth and correlate with mechanical tension...

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Autores principales: Alexandre Francou, Christopher De Bono, Robert G. Kelly
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/23683da733794ab082b1c8be084e700b
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spelling oai:doaj.org-article:23683da733794ab082b1c8be084e700b2021-12-02T17:06:17ZEpithelial tension in the second heart field promotes mouse heart tube elongation10.1038/ncomms147702041-1723https://doaj.org/article/23683da733794ab082b1c8be084e700b2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14770https://doaj.org/toc/2041-1723Epithelial progenitor cell growth in the second heart field contributes to heart morphogenesis but how this is regulated at the tissue level is unclear. Here, the authors show that cell elongation, polarized actomyosin and nuclear YAP/TAZ drive epithelial growth and correlate with mechanical tension.Alexandre FrancouChristopher De BonoRobert G. KellyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alexandre Francou
Christopher De Bono
Robert G. Kelly
Epithelial tension in the second heart field promotes mouse heart tube elongation
description Epithelial progenitor cell growth in the second heart field contributes to heart morphogenesis but how this is regulated at the tissue level is unclear. Here, the authors show that cell elongation, polarized actomyosin and nuclear YAP/TAZ drive epithelial growth and correlate with mechanical tension.
format article
author Alexandre Francou
Christopher De Bono
Robert G. Kelly
author_facet Alexandre Francou
Christopher De Bono
Robert G. Kelly
author_sort Alexandre Francou
title Epithelial tension in the second heart field promotes mouse heart tube elongation
title_short Epithelial tension in the second heart field promotes mouse heart tube elongation
title_full Epithelial tension in the second heart field promotes mouse heart tube elongation
title_fullStr Epithelial tension in the second heart field promotes mouse heart tube elongation
title_full_unstemmed Epithelial tension in the second heart field promotes mouse heart tube elongation
title_sort epithelial tension in the second heart field promotes mouse heart tube elongation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/23683da733794ab082b1c8be084e700b
work_keys_str_mv AT alexandrefrancou epithelialtensioninthesecondheartfieldpromotesmousehearttubeelongation
AT christopherdebono epithelialtensioninthesecondheartfieldpromotesmousehearttubeelongation
AT robertgkelly epithelialtensioninthesecondheartfieldpromotesmousehearttubeelongation
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