Variants of the 5′-terminal region of p53 mRNA influence the ribosomal scanning and translation efficiency

Abstract The p53 protein is one of the major cell cycle regulators. The protein is expressed as at least twelve protein isoforms resulting from the use of alternative promoters, alternative splicing or downstream initiation codons. Importantly, there is growing evidence that translation initiation o...

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Autores principales: Paulina Zydowicz-Machtel, Agata Swiatkowska, Łukasz Popenda, Agnieszka Gorska, Jerzy Ciesiołka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2374480777814c4480e748fa32df6905
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