FDG-PET predicts bone invasion and prognosis in patients with oral squamous cell carcinoma

Abstract 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) is widely used for tumor staging. This study sought to determine the relationship of preoperative primary tumor SUVmax (tSUVmax) with the clinicopathological features of patients with OSCC and to compare the prognostic ability of...

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Autores principales: Nan-Chin Lin, I-Hsien Su, Jui-Ting Hsu, Kuo-Yang Tsai, Michael Y. C. Chen
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2374e68473d94bcab8069ed7a42962fd
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spelling oai:doaj.org-article:2374e68473d94bcab8069ed7a42962fd2021-12-02T16:06:44ZFDG-PET predicts bone invasion and prognosis in patients with oral squamous cell carcinoma10.1038/s41598-021-94567-w2045-2322https://doaj.org/article/2374e68473d94bcab8069ed7a42962fd2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94567-whttps://doaj.org/toc/2045-2322Abstract 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) is widely used for tumor staging. This study sought to determine the relationship of preoperative primary tumor SUVmax (tSUVmax) with the clinicopathological features of patients with OSCC and to compare the prognostic ability of tSUVmax with that of other recurrence factors. Data of 340 patients with OSCC who were diagnosed, treated, and followed up at the Changhua Christian Hospital were retrospectively analyzed. Only patients with OSCC arising from gingiva, palate, floor of the mouth, and retromolar trigone and those who had received preoperative FDG-PET within 2 weeks before surgery were included. tSUVmax value > 9.2 was the strong predictor of bone invasion (area under the receiver operating characteristic curve, 0.844). tSUVmax value > 7.2 showed a strong association with advanced pathological T stage and recurrence factors and was associated with poor survival; tSUVmax > 7.2 showed stronger predictive power for poor disease-free survival (DFS) than pT stage and the other recurrence factors related to primary tumor. FDG-PET can be a useful supplement to contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging for diagnosing bone invasion by OSCC. The tSUVmax value was an independent predictor of DFS in this study.Nan-Chin LinI-Hsien SuJui-Ting HsuKuo-Yang TsaiMichael Y. C. ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Nan-Chin Lin
I-Hsien Su
Jui-Ting Hsu
Kuo-Yang Tsai
Michael Y. C. Chen
FDG-PET predicts bone invasion and prognosis in patients with oral squamous cell carcinoma
description Abstract 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) is widely used for tumor staging. This study sought to determine the relationship of preoperative primary tumor SUVmax (tSUVmax) with the clinicopathological features of patients with OSCC and to compare the prognostic ability of tSUVmax with that of other recurrence factors. Data of 340 patients with OSCC who were diagnosed, treated, and followed up at the Changhua Christian Hospital were retrospectively analyzed. Only patients with OSCC arising from gingiva, palate, floor of the mouth, and retromolar trigone and those who had received preoperative FDG-PET within 2 weeks before surgery were included. tSUVmax value > 9.2 was the strong predictor of bone invasion (area under the receiver operating characteristic curve, 0.844). tSUVmax value > 7.2 showed a strong association with advanced pathological T stage and recurrence factors and was associated with poor survival; tSUVmax > 7.2 showed stronger predictive power for poor disease-free survival (DFS) than pT stage and the other recurrence factors related to primary tumor. FDG-PET can be a useful supplement to contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging for diagnosing bone invasion by OSCC. The tSUVmax value was an independent predictor of DFS in this study.
format article
author Nan-Chin Lin
I-Hsien Su
Jui-Ting Hsu
Kuo-Yang Tsai
Michael Y. C. Chen
author_facet Nan-Chin Lin
I-Hsien Su
Jui-Ting Hsu
Kuo-Yang Tsai
Michael Y. C. Chen
author_sort Nan-Chin Lin
title FDG-PET predicts bone invasion and prognosis in patients with oral squamous cell carcinoma
title_short FDG-PET predicts bone invasion and prognosis in patients with oral squamous cell carcinoma
title_full FDG-PET predicts bone invasion and prognosis in patients with oral squamous cell carcinoma
title_fullStr FDG-PET predicts bone invasion and prognosis in patients with oral squamous cell carcinoma
title_full_unstemmed FDG-PET predicts bone invasion and prognosis in patients with oral squamous cell carcinoma
title_sort fdg-pet predicts bone invasion and prognosis in patients with oral squamous cell carcinoma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2374e68473d94bcab8069ed7a42962fd
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