Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study

Abstract The control of distant metastasis in oral squamous cell carcinoma is an important determinant of improved prognosis. The study aimed to identify risk factors for distant metastasis in patients with locoregionally controlled oral carcinoma. We identified 982 patients with oral squamous cell...

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Autores principales:	Hirofumi Tomioka, Yuko Yamagata, Yu Oikawa, Toshimitsu Ohsako, Takuma Kugimoto, Takeshi Kuroshima, Hideaki Hirai, Hiroaki Shimamoto, Hiroyuki Harada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23763232dbad4dc6a8632647a4e6ca90
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spelling	oai:doaj.org-article:23763232dbad4dc6a8632647a4e6ca902021-12-02T11:35:53ZRisk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study10.1038/s41598-021-84704-w2045-2322https://doaj.org/article/23763232dbad4dc6a8632647a4e6ca902021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84704-whttps://doaj.org/toc/2045-2322Abstract The control of distant metastasis in oral squamous cell carcinoma is an important determinant of improved prognosis. The study aimed to identify risk factors for distant metastasis in patients with locoregionally controlled oral carcinoma. We identified 982 patients with oral squamous cell carcinoma treated at our hospital between January 2008 and December 2017. After excluding patients with distant metastasis at initial treatment, patients with metastasis to the oral cavity, those receiving palliative treatment, and those lacking follow-up data, 941 patients were selected. Finally, among these 941 patients, 887 with locoregionally controlled oral squamous cell carcinoma were included in the study. Among the 887 patients, 36 had confirmed distant metastasis (4.1%), and the lung was the most common site (31/36 patients, 86.1%). Multivariate analysis showed that the incidence of primary intraosseous carcinoma of the mandible, cervical lymph node metastasis at levels IV and V, and the presence of pathological extranodal extension were significant risk factors for distant metastasis. When treating patients with oral squamous cell carcinoma who are positive for the aforementioned risk factors, the possibility of developing distant metastases must be accounted for, and aggressive treatment should be planned accordingly.Hirofumi TomiokaYuko YamagataYu OikawaToshimitsu OhsakoTakuma KugimotoTakeshi KuroshimaHideaki HiraiHiroaki ShimamotoHiroyuki HaradaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hirofumi Tomioka Yuko Yamagata Yu Oikawa Toshimitsu Ohsako Takuma Kugimoto Takeshi Kuroshima Hideaki Hirai Hiroaki Shimamoto Hiroyuki Harada Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study
description	Abstract The control of distant metastasis in oral squamous cell carcinoma is an important determinant of improved prognosis. The study aimed to identify risk factors for distant metastasis in patients with locoregionally controlled oral carcinoma. We identified 982 patients with oral squamous cell carcinoma treated at our hospital between January 2008 and December 2017. After excluding patients with distant metastasis at initial treatment, patients with metastasis to the oral cavity, those receiving palliative treatment, and those lacking follow-up data, 941 patients were selected. Finally, among these 941 patients, 887 with locoregionally controlled oral squamous cell carcinoma were included in the study. Among the 887 patients, 36 had confirmed distant metastasis (4.1%), and the lung was the most common site (31/36 patients, 86.1%). Multivariate analysis showed that the incidence of primary intraosseous carcinoma of the mandible, cervical lymph node metastasis at levels IV and V, and the presence of pathological extranodal extension were significant risk factors for distant metastasis. When treating patients with oral squamous cell carcinoma who are positive for the aforementioned risk factors, the possibility of developing distant metastases must be accounted for, and aggressive treatment should be planned accordingly.
format	article
author	Hirofumi Tomioka Yuko Yamagata Yu Oikawa Toshimitsu Ohsako Takuma Kugimoto Takeshi Kuroshima Hideaki Hirai Hiroaki Shimamoto Hiroyuki Harada
author_facet	Hirofumi Tomioka Yuko Yamagata Yu Oikawa Toshimitsu Ohsako Takuma Kugimoto Takeshi Kuroshima Hideaki Hirai Hiroaki Shimamoto Hiroyuki Harada
author_sort	Hirofumi Tomioka
title	Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study
title_short	Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study
title_full	Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study
title_fullStr	Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study
title_full_unstemmed	Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study
title_sort	risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23763232dbad4dc6a8632647a4e6ca90
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Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study

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