Herpes simplex virus 1 and the risk of dementia: a population-based study

Abstract Herpes simplex virus 1 (HSV1) is a neuroinvasive virus capable of entering the brain which makes it a candidate pathogen for increasing risk of dementia. Previous studies are inconsistent in their findings regarding the link between HSV1 and dementia, therefore, we investigated how HSV1 rel...

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Autores principales:	Meghan J. Murphy, Lana Fani, M. Kamran Ikram, Mohsen Ghanbari, M. Arfan Ikram
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23764de55bc6447aa2f82d32e924c624
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spelling	oai:doaj.org-article:23764de55bc6447aa2f82d32e924c6242021-12-02T18:27:47ZHerpes simplex virus 1 and the risk of dementia: a population-based study10.1038/s41598-021-87963-92045-2322https://doaj.org/article/23764de55bc6447aa2f82d32e924c6242021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87963-9https://doaj.org/toc/2045-2322Abstract Herpes simplex virus 1 (HSV1) is a neuroinvasive virus capable of entering the brain which makes it a candidate pathogen for increasing risk of dementia. Previous studies are inconsistent in their findings regarding the link between HSV1 and dementia, therefore, we investigated how HSV1 relates to cognitive decline and dementia risk using data from a population-based study. We measured HSV1 immunoglobulin (IgG) antibodies in serum collected between 2002 and 2005 from participants of the Rotterdam Study. We used linear regression to determine HSV1 in relation to change in cognitive performance during 2 consecutive examination rounds on average 6.5 years apart. Next, we determined the association of HSV1 with risk of dementia (until 2016) using a Cox regression model. We repeated analyses for Alzheimer’s disease. All models were adjusted for age, sex, cardiovascular risk factors, and apolipoprotein E genotype. Of 1915 non-demented participants (mean age 71.3 years, 56.7% women), with an average follow-up time of 9.1 years, 244 participants developed dementia (of whom 203 Alzheimer’s disease). HSV1 seropositivity was associated with decline in global cognition (mean difference of HSV1 seropositive vs seronegative per standard deviation decrease in global cognition − 0.16; 95% confidence interval (95%CI), − 0.26; − 0.07), as well as separate cognitive domains, namely memory, information processing, and executive function, but not motor function. Finally, HSV1 seropositivity was not associated with risk of dementia (adjusted hazard ratio 1.18, 95% CI 0.83; 1.68), similar for Alzheimer’s disease. HSV1 is associated with cognitive decline but not with incident dementia in the general population. These data suggest HSV1 to be associated only with subtle cognitive disturbances but not with greater cognitive disorders that result in dementia.Meghan J. MurphyLana FaniM. Kamran IkramMohsen GhanbariM. Arfan IkramNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meghan J. Murphy Lana Fani M. Kamran Ikram Mohsen Ghanbari M. Arfan Ikram Herpes simplex virus 1 and the risk of dementia: a population-based study
description	Abstract Herpes simplex virus 1 (HSV1) is a neuroinvasive virus capable of entering the brain which makes it a candidate pathogen for increasing risk of dementia. Previous studies are inconsistent in their findings regarding the link between HSV1 and dementia, therefore, we investigated how HSV1 relates to cognitive decline and dementia risk using data from a population-based study. We measured HSV1 immunoglobulin (IgG) antibodies in serum collected between 2002 and 2005 from participants of the Rotterdam Study. We used linear regression to determine HSV1 in relation to change in cognitive performance during 2 consecutive examination rounds on average 6.5 years apart. Next, we determined the association of HSV1 with risk of dementia (until 2016) using a Cox regression model. We repeated analyses for Alzheimer’s disease. All models were adjusted for age, sex, cardiovascular risk factors, and apolipoprotein E genotype. Of 1915 non-demented participants (mean age 71.3 years, 56.7% women), with an average follow-up time of 9.1 years, 244 participants developed dementia (of whom 203 Alzheimer’s disease). HSV1 seropositivity was associated with decline in global cognition (mean difference of HSV1 seropositive vs seronegative per standard deviation decrease in global cognition − 0.16; 95% confidence interval (95%CI), − 0.26; − 0.07), as well as separate cognitive domains, namely memory, information processing, and executive function, but not motor function. Finally, HSV1 seropositivity was not associated with risk of dementia (adjusted hazard ratio 1.18, 95% CI 0.83; 1.68), similar for Alzheimer’s disease. HSV1 is associated with cognitive decline but not with incident dementia in the general population. These data suggest HSV1 to be associated only with subtle cognitive disturbances but not with greater cognitive disorders that result in dementia.
format	article
author	Meghan J. Murphy Lana Fani M. Kamran Ikram Mohsen Ghanbari M. Arfan Ikram
author_facet	Meghan J. Murphy Lana Fani M. Kamran Ikram Mohsen Ghanbari M. Arfan Ikram
author_sort	Meghan J. Murphy
title	Herpes simplex virus 1 and the risk of dementia: a population-based study
title_short	Herpes simplex virus 1 and the risk of dementia: a population-based study
title_full	Herpes simplex virus 1 and the risk of dementia: a population-based study
title_fullStr	Herpes simplex virus 1 and the risk of dementia: a population-based study
title_full_unstemmed	Herpes simplex virus 1 and the risk of dementia: a population-based study
title_sort	herpes simplex virus 1 and the risk of dementia: a population-based study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23764de55bc6447aa2f82d32e924c624
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Herpes simplex virus 1 and the risk of dementia: a population-based study

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