Аrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus

Aim. To evolve the association between cardiac autonomic function and arterial stiffness in children and adolescents with type 1 diabetes mellitus (T1DM). Materials and methods. 72 T1DM patients aged 7?18 years without history of macrovascular complications or renal disease, including microalbumin...

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Autor principal:	Dmitriy Nikitich Laptev
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	type 1 diabetes mellitus autonomic neuropathy heart rate variability arterial stiffness blood pressure qt interval Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/237dab59d604423cb77a1e9a0729ff52
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spelling	oai:doaj.org-article:237dab59d604423cb77a1e9a0729ff522021-11-14T09:00:19ZАrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus2072-03512072-037810.14341/DM2015194-100https://doaj.org/article/237dab59d604423cb77a1e9a0729ff522015-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6776https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To evolve the association between cardiac autonomic function and arterial stiffness in children and adolescents with type 1 diabetes mellitus (T1DM). Materials and methods. 72 T1DM patients aged 7?18 years without history of macrovascular complications or renal disease, including microalbuminuria, were involved in the study. Cardiac function was assessed by the cardiovascular tests and 24-hour ECG monitoring with automatic calculation of QT interval and heart rate variability (HRV) parameters. Artery stiffness was assessed by measurement of pulse wave velocity (PWV) and augmentation index (AI) obtained from arterial blood pressure monitoring for 24 hours. Results. Estimated prevalence of cardiovascular autonomic neuropathy (CAN) was 31,9%. CAN+ patients had significantly higher PWV and AI than those without CAN. A negative correlation between PWV and AI with some cardiovascular tests and HRV parameters was observed. In multivariable analysis, AI was independent predictor of autonomic dysfunction defined as number of positive cardiovascular tests, HRV parameters below normal values and prolongation of QT interval (?. =0,18; p=0,035). Conclusion. Cardiac autonomic function is an independent predictor of arterial stiffness, in children and adolescents with T1D without macrovascular and renal complications. The presence of cardiovascular risk factors and arterial stiffness in children and adolescents with T1DM may contribute to the increased cardiovascular morbidity and mortality in adulthood in patients with CAN.Dmitriy Nikitich LaptevEndocrinology Research Centrearticletype 1 diabetes mellitusautonomic neuropathyheart rate variabilityarterial stiffnessblood pressureqt intervalNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 1, Pp 94-100 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes mellitus autonomic neuropathy heart rate variability arterial stiffness blood pressure qt interval Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes mellitus autonomic neuropathy heart rate variability arterial stiffness blood pressure qt interval Nutritional diseases. Deficiency diseases RC620-627 Dmitriy Nikitich Laptev Аrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus
description	Aim. To evolve the association between cardiac autonomic function and arterial stiffness in children and adolescents with type 1 diabetes mellitus (T1DM). Materials and methods. 72 T1DM patients aged 7?18 years without history of macrovascular complications or renal disease, including microalbuminuria, were involved in the study. Cardiac function was assessed by the cardiovascular tests and 24-hour ECG monitoring with automatic calculation of QT interval and heart rate variability (HRV) parameters. Artery stiffness was assessed by measurement of pulse wave velocity (PWV) and augmentation index (AI) obtained from arterial blood pressure monitoring for 24 hours. Results. Estimated prevalence of cardiovascular autonomic neuropathy (CAN) was 31,9%. CAN+ patients had significantly higher PWV and AI than those without CAN. A negative correlation between PWV and AI with some cardiovascular tests and HRV parameters was observed. In multivariable analysis, AI was independent predictor of autonomic dysfunction defined as number of positive cardiovascular tests, HRV parameters below normal values and prolongation of QT interval (?. =0,18; p=0,035). Conclusion. Cardiac autonomic function is an independent predictor of arterial stiffness, in children and adolescents with T1D without macrovascular and renal complications. The presence of cardiovascular risk factors and arterial stiffness in children and adolescents with T1DM may contribute to the increased cardiovascular morbidity and mortality in adulthood in patients with CAN.
format	article
author	Dmitriy Nikitich Laptev
author_facet	Dmitriy Nikitich Laptev
author_sort	Dmitriy Nikitich Laptev
title	Аrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus
title_short	Аrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus
title_full	Аrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus
title_fullStr	Аrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus
title_full_unstemmed	Аrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus
title_sort	аrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/237dab59d604423cb77a1e9a0729ff52
work_keys_str_mv	AT dmitriynikitichlaptev arterialstiffnessandcardiovascularautonomicneuropathyrelationshipinchildrenandadolescentswithtype1diabetesmellitus
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Аrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus

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