Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.

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Autores principales: Marco Heestermans, Clément Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A. Friese, Mathias Gelderblom, Albert Sickmann, Roger J. S. Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M. Butler, Ophira Salomon, Evi X. Stavrou, Thomas Renné
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/23842f92b8124cd4863e0db2254038e6
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spelling oai:doaj.org-article:23842f92b8124cd4863e0db2254038e62021-12-02T18:48:24ZIdentification of the factor XII contact activation site enables sensitive coagulation diagnostics10.1038/s41467-021-25888-72041-1723https://doaj.org/article/23842f92b8124cd4863e0db2254038e62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25888-7https://doaj.org/toc/2041-1723Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.Marco HeestermansClément NaudinReiner K. MailerSandra KonrathKristin KlaetschkeAnne JämsäMaike FryeCarsten DeppermannGiordano PulaPiotr KutaManuel A. FrieseMathias GelderblomAlbert SickmannRoger J. S. PrestonJerzy-Roch NoferStefan Rose-JohnLynn M. ButlerOphira SalomonEvi X. StavrouThomas RennéNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marco Heestermans
Clément Naudin
Reiner K. Mailer
Sandra Konrath
Kristin Klaetschke
Anne Jämsä
Maike Frye
Carsten Deppermann
Giordano Pula
Piotr Kuta
Manuel A. Friese
Mathias Gelderblom
Albert Sickmann
Roger J. S. Preston
Jerzy-Roch Nofer
Stefan Rose-John
Lynn M. Butler
Ophira Salomon
Evi X. Stavrou
Thomas Renné
Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
description Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.
format article
author Marco Heestermans
Clément Naudin
Reiner K. Mailer
Sandra Konrath
Kristin Klaetschke
Anne Jämsä
Maike Frye
Carsten Deppermann
Giordano Pula
Piotr Kuta
Manuel A. Friese
Mathias Gelderblom
Albert Sickmann
Roger J. S. Preston
Jerzy-Roch Nofer
Stefan Rose-John
Lynn M. Butler
Ophira Salomon
Evi X. Stavrou
Thomas Renné
author_facet Marco Heestermans
Clément Naudin
Reiner K. Mailer
Sandra Konrath
Kristin Klaetschke
Anne Jämsä
Maike Frye
Carsten Deppermann
Giordano Pula
Piotr Kuta
Manuel A. Friese
Mathias Gelderblom
Albert Sickmann
Roger J. S. Preston
Jerzy-Roch Nofer
Stefan Rose-John
Lynn M. Butler
Ophira Salomon
Evi X. Stavrou
Thomas Renné
author_sort Marco Heestermans
title Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
title_short Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
title_full Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
title_fullStr Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
title_full_unstemmed Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
title_sort identification of the factor xii contact activation site enables sensitive coagulation diagnostics
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/23842f92b8124cd4863e0db2254038e6
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