Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis.

<h4>Background</h4>MicroRNAs (miRNAs) are small, endogenously expressed non-coding RNAs that regulate mRNAs post-transcriptionally. Previous studies have explored miRNA evolutionary trend, but evolutionary history and pattern in the miRNA world are still not fully clear. In the paper, we...

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Autores principales:	Li Guo, Beili Sun, Fei Sang, Wei Wang, Zuhong Lu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23866fc342a54b3ba3f8875149d1dfcc
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spelling	oai:doaj.org-article:23866fc342a54b3ba3f8875149d1dfcc2021-11-25T06:27:54ZHaplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis.1932-620310.1371/journal.pone.0007944https://doaj.org/article/23866fc342a54b3ba3f8875149d1dfcc2009-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19956752/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>MicroRNAs (miRNAs) are small, endogenously expressed non-coding RNAs that regulate mRNAs post-transcriptionally. Previous studies have explored miRNA evolutionary trend, but evolutionary history and pattern in the miRNA world are still not fully clear. In the paper, we intended to analyze miRNA haplotype distribution and evolutionary network by analyzing miRNA sequences of miR-17 and miR-124 families across animal species as special populations.<h4>Principal findings</h4>31 haplotypes were detected in miR-17 family while only 9 haplotypes were defined in miR-124 family. The complex miR-17 family was mainly distributed in vertebrates, but miR-124 was shared by more animal species from Caenorhabditis to Homo and had a wide distribution spectrum. Some haplotypes of the two miRNA families appeared discontinuous distributions across animals. Compared with a simple phylogenetic network in miR-124 family, miR-17 family indicated a complex network with some median vectors that might be lost ancestral or potential miRNA haplotypes. By analyzing different miRNAs across 12 animal species, we found these small RNAs showed different haplotype diversities, haplotype distributions and phylogenetic networks.<h4>Conclusions</h4>Different miRNAs had quite different haplotype distributions and evolutionary patterns. Discontinuous distributions of miRNAs and median vectors in phylogenetic networks implied more members in the miRNA world. miRNA may be an excellent phylogenetic marker to discover its evolutionary history and pattern across the animal kingdom.Li GuoBeili SunFei SangWei WangZuhong LuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 11, p e7944 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Guo Beili Sun Fei Sang Wei Wang Zuhong Lu Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis.
description	<h4>Background</h4>MicroRNAs (miRNAs) are small, endogenously expressed non-coding RNAs that regulate mRNAs post-transcriptionally. Previous studies have explored miRNA evolutionary trend, but evolutionary history and pattern in the miRNA world are still not fully clear. In the paper, we intended to analyze miRNA haplotype distribution and evolutionary network by analyzing miRNA sequences of miR-17 and miR-124 families across animal species as special populations.<h4>Principal findings</h4>31 haplotypes were detected in miR-17 family while only 9 haplotypes were defined in miR-124 family. The complex miR-17 family was mainly distributed in vertebrates, but miR-124 was shared by more animal species from Caenorhabditis to Homo and had a wide distribution spectrum. Some haplotypes of the two miRNA families appeared discontinuous distributions across animals. Compared with a simple phylogenetic network in miR-124 family, miR-17 family indicated a complex network with some median vectors that might be lost ancestral or potential miRNA haplotypes. By analyzing different miRNAs across 12 animal species, we found these small RNAs showed different haplotype diversities, haplotype distributions and phylogenetic networks.<h4>Conclusions</h4>Different miRNAs had quite different haplotype distributions and evolutionary patterns. Discontinuous distributions of miRNAs and median vectors in phylogenetic networks implied more members in the miRNA world. miRNA may be an excellent phylogenetic marker to discover its evolutionary history and pattern across the animal kingdom.
format	article
author	Li Guo Beili Sun Fei Sang Wei Wang Zuhong Lu
author_facet	Li Guo Beili Sun Fei Sang Wei Wang Zuhong Lu
author_sort	Li Guo
title	Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis.
title_short	Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis.
title_full	Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis.
title_fullStr	Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis.
title_full_unstemmed	Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis.
title_sort	haplotype distribution and evolutionary pattern of mir-17 and mir-124 families based on population analysis.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/23866fc342a54b3ba3f8875149d1dfcc
work_keys_str_mv	AT liguo haplotypedistributionandevolutionarypatternofmir17andmir124familiesbasedonpopulationanalysis AT beilisun haplotypedistributionandevolutionarypatternofmir17andmir124familiesbasedonpopulationanalysis AT feisang haplotypedistributionandevolutionarypatternofmir17andmir124familiesbasedonpopulationanalysis AT weiwang haplotypedistributionandevolutionarypatternofmir17andmir124familiesbasedonpopulationanalysis AT zuhonglu haplotypedistributionandevolutionarypatternofmir17andmir124familiesbasedonpopulationanalysis
_version_	1718413668737089536

Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis.

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