Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis
Dysfunction of autophagy in plaque macrophages aggravates atherosclerosis. Here the authors show that induction of macrophage autophagy–lysosomal biogenesis either genetically by overexpression of the master transcriptional regulator of this process, TFEB, or pharmacologically with trehalose is athe...
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Nature Portfolio
2017
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| Acceso en línea: | https://doaj.org/article/2386c202410647229c348496bc117d5b |
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oai:doaj.org-article:2386c202410647229c348496bc117d5b2021-12-02T14:42:21ZExploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis10.1038/ncomms157502041-1723https://doaj.org/article/2386c202410647229c348496bc117d5b2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15750https://doaj.org/toc/2041-1723Dysfunction of autophagy in plaque macrophages aggravates atherosclerosis. Here the authors show that induction of macrophage autophagy–lysosomal biogenesis either genetically by overexpression of the master transcriptional regulator of this process, TFEB, or pharmacologically with trehalose is atheroprotective.Ismail SerginTrent D. EvansXiangyu ZhangSomashubhra BhattacharyaCarl J. StokesEric SongSahl AliBabak DehestaniKaryn B. HollowayPaul S. MicevychAli JavaheriJan R. CrowleyAndrea BallabioJoel D. SchillingSlava EpelmanConrad C. WeihlAbhinav DiwanDaping FanMohamed A. ZayedBabak RazaniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-20 (2017) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ismail Sergin Trent D. Evans Xiangyu Zhang Somashubhra Bhattacharya Carl J. Stokes Eric Song Sahl Ali Babak Dehestani Karyn B. Holloway Paul S. Micevych Ali Javaheri Jan R. Crowley Andrea Ballabio Joel D. Schilling Slava Epelman Conrad C. Weihl Abhinav Diwan Daping Fan Mohamed A. Zayed Babak Razani Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis |
| description |
Dysfunction of autophagy in plaque macrophages aggravates atherosclerosis. Here the authors show that induction of macrophage autophagy–lysosomal biogenesis either genetically by overexpression of the master transcriptional regulator of this process, TFEB, or pharmacologically with trehalose is atheroprotective. |
| format |
article |
| author |
Ismail Sergin Trent D. Evans Xiangyu Zhang Somashubhra Bhattacharya Carl J. Stokes Eric Song Sahl Ali Babak Dehestani Karyn B. Holloway Paul S. Micevych Ali Javaheri Jan R. Crowley Andrea Ballabio Joel D. Schilling Slava Epelman Conrad C. Weihl Abhinav Diwan Daping Fan Mohamed A. Zayed Babak Razani |
| author_facet |
Ismail Sergin Trent D. Evans Xiangyu Zhang Somashubhra Bhattacharya Carl J. Stokes Eric Song Sahl Ali Babak Dehestani Karyn B. Holloway Paul S. Micevych Ali Javaheri Jan R. Crowley Andrea Ballabio Joel D. Schilling Slava Epelman Conrad C. Weihl Abhinav Diwan Daping Fan Mohamed A. Zayed Babak Razani |
| author_sort |
Ismail Sergin |
| title |
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis |
| title_short |
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis |
| title_full |
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis |
| title_fullStr |
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis |
| title_full_unstemmed |
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis |
| title_sort |
exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/2386c202410647229c348496bc117d5b |
| work_keys_str_mv |
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