Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

In vivo reprogramming of reactive glia using transfection of a single transcription factor has been described before by these authors and applied to models of neurodegeneration. Here the authors use this procedure in the R6/2 mouse model of Huntington’s disease, targeting astrocytes in the striatum,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zheng Wu, Matthew Parry, Xiao-Yi Hou, Min-Hui Liu, Hui Wang, Rachel Cain, Zi-Fei Pei, Yu-Chen Chen, Zi-Yuan Guo, Sambangi Abhijeet, Gong Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2387e888eee84d4b8badfe7bc66564ae
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2387e888eee84d4b8badfe7bc66564ae
record_format	dspace
spelling	oai:doaj.org-article:2387e888eee84d4b8badfe7bc66564ae2021-12-02T14:40:51ZGene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease10.1038/s41467-020-14855-32041-1723https://doaj.org/article/2387e888eee84d4b8badfe7bc66564ae2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14855-3https://doaj.org/toc/2041-1723In vivo reprogramming of reactive glia using transfection of a single transcription factor has been described before by these authors and applied to models of neurodegeneration. Here the authors use this procedure in the R6/2 mouse model of Huntington’s disease, targeting astrocytes in the striatum, converting them to GABAergic neurons.Zheng WuMatthew ParryXiao-Yi HouMin-Hui LiuHui WangRachel CainZi-Fei PeiYu-Chen ChenZi-Yuan GuoSambangi AbhijeetGong ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zheng Wu Matthew Parry Xiao-Yi Hou Min-Hui Liu Hui Wang Rachel Cain Zi-Fei Pei Yu-Chen Chen Zi-Yuan Guo Sambangi Abhijeet Gong Chen Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease
description	In vivo reprogramming of reactive glia using transfection of a single transcription factor has been described before by these authors and applied to models of neurodegeneration. Here the authors use this procedure in the R6/2 mouse model of Huntington’s disease, targeting astrocytes in the striatum, converting them to GABAergic neurons.
format	article
author	Zheng Wu Matthew Parry Xiao-Yi Hou Min-Hui Liu Hui Wang Rachel Cain Zi-Fei Pei Yu-Chen Chen Zi-Yuan Guo Sambangi Abhijeet Gong Chen
author_facet	Zheng Wu Matthew Parry Xiao-Yi Hou Min-Hui Liu Hui Wang Rachel Cain Zi-Fei Pei Yu-Chen Chen Zi-Yuan Guo Sambangi Abhijeet Gong Chen
author_sort	Zheng Wu
title	Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease
title_short	Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease
title_full	Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease
title_fullStr	Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease
title_full_unstemmed	Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease
title_sort	gene therapy conversion of striatal astrocytes into gabaergic neurons in mouse models of huntington’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2387e888eee84d4b8badfe7bc66564ae
work_keys_str_mv	AT zhengwu genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease AT matthewparry genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease AT xiaoyihou genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease AT minhuiliu genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease AT huiwang genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease AT rachelcain genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease AT zifeipei genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease AT yuchenchen genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease AT ziyuanguo genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease AT sambangiabhijeet genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease AT gongchen genetherapyconversionofstriatalastrocytesintogabaergicneuronsinmousemodelsofhuntingtonsdisease
_version_	1718390099411992576

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

Ejemplares similares