Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET

Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET

MxA (myxovirus resistance protein A) is a viral restriction factor whose activity depends on self-assembly into polymeric rings and helical filaments. Here the authors reveal the conformational movements involved in generating torque within polymeric MxA molecules and the dynamic conformational chan...

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Autores principales: Yang Chen, Lei Zhang, Laura Graf, Bing Yu, Yue Liu, Georg Kochs, Yongfang Zhao, Song Gao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/238a897e890a4cd0ae63f68efa6cfb0a
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spelling oai:doaj.org-article:238a897e890a4cd0ae63f68efa6cfb0a2021-12-02T14:41:08ZConformational dynamics of dynamin-like MxA revealed by single-molecule FRET10.1038/ncomms157442041-1723https://doaj.org/article/238a897e890a4cd0ae63f68efa6cfb0a2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15744https://doaj.org/toc/2041-1723MxA (myxovirus resistance protein A) is a viral restriction factor whose activity depends on self-assembly into polymeric rings and helical filaments. Here the authors reveal the conformational movements involved in generating torque within polymeric MxA molecules and the dynamic conformational changes that occur upon GTP loading and hydrolysis.Yang ChenLei ZhangLaura GrafBing YuYue LiuGeorg KochsYongfang ZhaoSong GaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yang Chen
Lei Zhang
Laura Graf
Bing Yu
Yue Liu
Georg Kochs
Yongfang Zhao
Song Gao
Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
description MxA (myxovirus resistance protein A) is a viral restriction factor whose activity depends on self-assembly into polymeric rings and helical filaments. Here the authors reveal the conformational movements involved in generating torque within polymeric MxA molecules and the dynamic conformational changes that occur upon GTP loading and hydrolysis.
format article
author Yang Chen
Lei Zhang
Laura Graf
Bing Yu
Yue Liu
Georg Kochs
Yongfang Zhao
Song Gao
author_facet Yang Chen
Lei Zhang
Laura Graf
Bing Yu
Yue Liu
Georg Kochs
Yongfang Zhao
Song Gao
author_sort Yang Chen
title Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
title_short Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
title_full Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
title_fullStr Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
title_full_unstemmed Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
title_sort conformational dynamics of dynamin-like mxa revealed by single-molecule fret
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/238a897e890a4cd0ae63f68efa6cfb0a
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AT leizhang conformationaldynamicsofdynaminlikemxarevealedbysinglemoleculefret
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AT bingyu conformationaldynamicsofdynaminlikemxarevealedbysinglemoleculefret
AT yueliu conformationaldynamicsofdynaminlikemxarevealedbysinglemoleculefret
AT georgkochs conformationaldynamicsofdynaminlikemxarevealedbysinglemoleculefret
AT yongfangzhao conformationaldynamicsofdynaminlikemxarevealedbysinglemoleculefret
AT songgao conformationaldynamicsofdynaminlikemxarevealedbysinglemoleculefret
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