Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone
The dopamine D2 receptor (D2R) is a GPCR and an important drug target for schizophrenia treatment. Here, the authors present the crystal structure of human D2R in complex with the antipsychotic drug spiperone, which is of interest for designing antipsychotics with improved receptor selectivity.
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Nature Portfolio
2020
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oai:doaj.org-article:238cb5436dc34fefbac7633410b314052021-12-02T13:27:31ZStructure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone10.1038/s41467-020-20221-02041-1723https://doaj.org/article/238cb5436dc34fefbac7633410b314052020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20221-0https://doaj.org/toc/2041-1723The dopamine D2 receptor (D2R) is a GPCR and an important drug target for schizophrenia treatment. Here, the authors present the crystal structure of human D2R in complex with the antipsychotic drug spiperone, which is of interest for designing antipsychotics with improved receptor selectivity.Dohyun ImAsuka InoueTakaaki FujiwaraTakanori NakaneYasuaki YamanakaTomoko UemuraChihiro MoriYuki ShiimuraKanako Terakado KimuraHidetsugu AsadaNorimichi NomuraTomoyuki TanakaAyumi YamashitaEriko NangoKensuke TonoFrancois Marie Ngako KadjiJunken AokiSo IwataTatsuro ShimamuraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Dohyun Im Asuka Inoue Takaaki Fujiwara Takanori Nakane Yasuaki Yamanaka Tomoko Uemura Chihiro Mori Yuki Shiimura Kanako Terakado Kimura Hidetsugu Asada Norimichi Nomura Tomoyuki Tanaka Ayumi Yamashita Eriko Nango Kensuke Tono Francois Marie Ngako Kadji Junken Aoki So Iwata Tatsuro Shimamura Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone |
| description |
The dopamine D2 receptor (D2R) is a GPCR and an important drug target for schizophrenia treatment. Here, the authors present the crystal structure of human D2R in complex with the antipsychotic drug spiperone, which is of interest for designing antipsychotics with improved receptor selectivity. |
| format |
article |
| author |
Dohyun Im Asuka Inoue Takaaki Fujiwara Takanori Nakane Yasuaki Yamanaka Tomoko Uemura Chihiro Mori Yuki Shiimura Kanako Terakado Kimura Hidetsugu Asada Norimichi Nomura Tomoyuki Tanaka Ayumi Yamashita Eriko Nango Kensuke Tono Francois Marie Ngako Kadji Junken Aoki So Iwata Tatsuro Shimamura |
| author_facet |
Dohyun Im Asuka Inoue Takaaki Fujiwara Takanori Nakane Yasuaki Yamanaka Tomoko Uemura Chihiro Mori Yuki Shiimura Kanako Terakado Kimura Hidetsugu Asada Norimichi Nomura Tomoyuki Tanaka Ayumi Yamashita Eriko Nango Kensuke Tono Francois Marie Ngako Kadji Junken Aoki So Iwata Tatsuro Shimamura |
| author_sort |
Dohyun Im |
| title |
Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone |
| title_short |
Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone |
| title_full |
Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone |
| title_fullStr |
Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone |
| title_full_unstemmed |
Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone |
| title_sort |
structure of the dopamine d2 receptor in complex with the antipsychotic drug spiperone |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/238cb5436dc34fefbac7633410b31405 |
| work_keys_str_mv |
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