The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects

Cancer, as a mysterious and complex disease, has a multi-stage molecular process that uses the cellular molecular machine and multiple signaling pathways to its advantage. Cannabinoids, as terpenophenolic compounds and their derivatives, showed influences on immune system responses, inflammation, an...

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Autores principales:	Fatemeh Hosami, Maryam Haghparast Ghadimkhah, Vahid Salimi, Seyedeh Sara Ghorbanhosseini, Masoumeh Tavakoli-Yaraki
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cannabinoids Cannabinoid receptor Proliferation Angiogenesis Immune system Cancer Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/238e395b3ea1424fb1cb1dbf1a3f1f55
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spelling	oai:doaj.org-article:238e395b3ea1424fb1cb1dbf1a3f1f552021-11-14T04:29:11ZThe strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects0753-332210.1016/j.biopha.2021.112279https://doaj.org/article/238e395b3ea1424fb1cb1dbf1a3f1f552021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010635https://doaj.org/toc/0753-3322Cancer, as a mysterious and complex disease, has a multi-stage molecular process that uses the cellular molecular machine and multiple signaling pathways to its advantage. Cannabinoids, as terpenophenolic compounds and their derivatives, showed influences on immune system responses, inflammation, and cell growth that have sparked a growing interest in exploring their effects on cancer cell fate, as well. A large body of evidence in experimental models indicating the involvement of cannabinoids and their related receptors in cancer cell growth, development, and fate. In accordance, the present study provided insights regarding the strengths and limits of cannabinoids and their receptors in critical steps of tumorigenesis and its underlying molecular pathways such as; cancer cell proliferation, type of cell death pathway, angiogenesis, invasion, metastasis and, immune system response. Based on the results of the present study and due to the contribution of cannabinoids in various cancer cell growth control processes, these compounds cancer can be considered worthwhile in finding new alternatives for cancer therapy.Fatemeh HosamiMaryam Haghparast GhadimkhahVahid SalimiSeyedeh Sara GhorbanhosseiniMasoumeh Tavakoli-YarakiElsevierarticleCannabinoidsCannabinoid receptorProliferationAngiogenesisImmune systemCancerTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112279- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cannabinoids Cannabinoid receptor Proliferation Angiogenesis Immune system Cancer Therapeutics. Pharmacology RM1-950
spellingShingle	Cannabinoids Cannabinoid receptor Proliferation Angiogenesis Immune system Cancer Therapeutics. Pharmacology RM1-950 Fatemeh Hosami Maryam Haghparast Ghadimkhah Vahid Salimi Seyedeh Sara Ghorbanhosseini Masoumeh Tavakoli-Yaraki The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects
description	Cancer, as a mysterious and complex disease, has a multi-stage molecular process that uses the cellular molecular machine and multiple signaling pathways to its advantage. Cannabinoids, as terpenophenolic compounds and their derivatives, showed influences on immune system responses, inflammation, and cell growth that have sparked a growing interest in exploring their effects on cancer cell fate, as well. A large body of evidence in experimental models indicating the involvement of cannabinoids and their related receptors in cancer cell growth, development, and fate. In accordance, the present study provided insights regarding the strengths and limits of cannabinoids and their receptors in critical steps of tumorigenesis and its underlying molecular pathways such as; cancer cell proliferation, type of cell death pathway, angiogenesis, invasion, metastasis and, immune system response. Based on the results of the present study and due to the contribution of cannabinoids in various cancer cell growth control processes, these compounds cancer can be considered worthwhile in finding new alternatives for cancer therapy.
format	article
author	Fatemeh Hosami Maryam Haghparast Ghadimkhah Vahid Salimi Seyedeh Sara Ghorbanhosseini Masoumeh Tavakoli-Yaraki
author_facet	Fatemeh Hosami Maryam Haghparast Ghadimkhah Vahid Salimi Seyedeh Sara Ghorbanhosseini Masoumeh Tavakoli-Yaraki
author_sort	Fatemeh Hosami
title	The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects
title_short	The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects
title_full	The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects
title_fullStr	The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects
title_full_unstemmed	The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects
title_sort	strengths and limits of cannabinoids and their receptors in cancer: insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/238e395b3ea1424fb1cb1dbf1a3f1f55
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The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects

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