Disease progression modeling of Alzheimer’s disease according to education level

Abstract To develop a disease progression model of Alzheimer’s disease (AD) that shows cognitive decline from subjective cognitive impairments (SCI) to the end stage of AD dementia (ADD) and to investigate the effect of education level on the whole disease spectrum, we enrolled 565 patients who were...

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Autores principales:	Ko Woon Kim, Sook Young Woo, Seonwoo Kim, Hyemin Jang, Yeshin Kim, Soo Hyun Cho, Si Eun Kim, Seung Joo Kim, Byoung-Soo Shin, Hee Jin Kim, Duk L. Na, Sang Won Seo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23908a28c5ed4cfebfb3d7ecb177188a
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spelling	oai:doaj.org-article:23908a28c5ed4cfebfb3d7ecb177188a2021-12-02T18:36:13ZDisease progression modeling of Alzheimer’s disease according to education level10.1038/s41598-020-73911-62045-2322https://doaj.org/article/23908a28c5ed4cfebfb3d7ecb177188a2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-73911-6https://doaj.org/toc/2045-2322Abstract To develop a disease progression model of Alzheimer’s disease (AD) that shows cognitive decline from subjective cognitive impairments (SCI) to the end stage of AD dementia (ADD) and to investigate the effect of education level on the whole disease spectrum, we enrolled 565 patients who were followed up more than three times and had a clinical dementia rating sum of boxes (CDR-SB). Three cohorts, SCI (n = 85), amnestic mild cognitive impairment (AMCI, n = 240), and ADD (n = 240), were overlapped in two consecutive cohorts (SCI and AMCI, AMCI and ADD) to construct a model of disease course, and a model with multiple single-cohorts was estimated using a mixed-effect model. To examine the effect of education level on disease progression, the disease progression model was developed with data from lower (≤ 12) and higher (> 12) education groups. Disease progression takes 274.3 months (22.9 years) to advance from 0 to 18 points using the CDR-SB. Based on our predictive equation, it takes 116.5 months to progress from SCI to AMCI and 56.2 months to progress from AMCI to ADD. The rate of CDR-SB progression was different according to education level. The lower-education group showed faster CDR-SB progression from SCI to AMCI compared to the higher-education group, and this trend disappeared from AMCI to ADD. In the present study, we developed a disease progression model of AD spectrum from SCI to the end stage of ADD. Our disease modeling provides us with more understanding of the effect of education on cognitive trajectories.Ko Woon KimSook Young WooSeonwoo KimHyemin JangYeshin KimSoo Hyun ChoSi Eun KimSeung Joo KimByoung-Soo ShinHee Jin KimDuk L. NaSang Won SeoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ko Woon Kim Sook Young Woo Seonwoo Kim Hyemin Jang Yeshin Kim Soo Hyun Cho Si Eun Kim Seung Joo Kim Byoung-Soo Shin Hee Jin Kim Duk L. Na Sang Won Seo Disease progression modeling of Alzheimer’s disease according to education level
description	Abstract To develop a disease progression model of Alzheimer’s disease (AD) that shows cognitive decline from subjective cognitive impairments (SCI) to the end stage of AD dementia (ADD) and to investigate the effect of education level on the whole disease spectrum, we enrolled 565 patients who were followed up more than three times and had a clinical dementia rating sum of boxes (CDR-SB). Three cohorts, SCI (n = 85), amnestic mild cognitive impairment (AMCI, n = 240), and ADD (n = 240), were overlapped in two consecutive cohorts (SCI and AMCI, AMCI and ADD) to construct a model of disease course, and a model with multiple single-cohorts was estimated using a mixed-effect model. To examine the effect of education level on disease progression, the disease progression model was developed with data from lower (≤ 12) and higher (> 12) education groups. Disease progression takes 274.3 months (22.9 years) to advance from 0 to 18 points using the CDR-SB. Based on our predictive equation, it takes 116.5 months to progress from SCI to AMCI and 56.2 months to progress from AMCI to ADD. The rate of CDR-SB progression was different according to education level. The lower-education group showed faster CDR-SB progression from SCI to AMCI compared to the higher-education group, and this trend disappeared from AMCI to ADD. In the present study, we developed a disease progression model of AD spectrum from SCI to the end stage of ADD. Our disease modeling provides us with more understanding of the effect of education on cognitive trajectories.
format	article
author	Ko Woon Kim Sook Young Woo Seonwoo Kim Hyemin Jang Yeshin Kim Soo Hyun Cho Si Eun Kim Seung Joo Kim Byoung-Soo Shin Hee Jin Kim Duk L. Na Sang Won Seo
author_facet	Ko Woon Kim Sook Young Woo Seonwoo Kim Hyemin Jang Yeshin Kim Soo Hyun Cho Si Eun Kim Seung Joo Kim Byoung-Soo Shin Hee Jin Kim Duk L. Na Sang Won Seo
author_sort	Ko Woon Kim
title	Disease progression modeling of Alzheimer’s disease according to education level
title_short	Disease progression modeling of Alzheimer’s disease according to education level
title_full	Disease progression modeling of Alzheimer’s disease according to education level
title_fullStr	Disease progression modeling of Alzheimer’s disease according to education level
title_full_unstemmed	Disease progression modeling of Alzheimer’s disease according to education level
title_sort	disease progression modeling of alzheimer’s disease according to education level
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/23908a28c5ed4cfebfb3d7ecb177188a
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Disease progression modeling of Alzheimer’s disease according to education level

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