Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions

Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions

Neuroblastoma is a devastating tumour in children. Here, the authors analyse multi-region patient samples using genomics and transcriptomics, revealing temporal and spatial heterogeneity and questioning the reliability of single-biopsy based diagnostics.

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Auteurs principaux: Karin Schmelz, Joern Toedling, Matt Huska, Maja C. Cwikla, Louisa-Marie Kruetzfeldt, Jutta Proba, Peter F. Ambros, Inge M. Ambros, Sengül Boral, Marco Lodrini, Celine Y. Chen, Martin Burkert, Dennis Guergen, Annabell Szymansky, Kathy Astrahantseff, Annette Kuenkele, Kerstin Haase, Matthias Fischer, Hedwig E. Deubzer, Falk Hertwig, Patrick Hundsdoerfer, Anton G. Henssen, Roland F. Schwarz, Johannes H. Schulte, Angelika Eggert
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/2390ab09b04a41c28245bac3ed08f2c9
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Résumé:Neuroblastoma is a devastating tumour in children. Here, the authors analyse multi-region patient samples using genomics and transcriptomics, revealing temporal and spatial heterogeneity and questioning the reliability of single-biopsy based diagnostics.

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