Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions
Neuroblastoma is a devastating tumour in children. Here, the authors analyse multi-region patient samples using genomics and transcriptomics, revealing temporal and spatial heterogeneity and questioning the reliability of single-biopsy based diagnostics.
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Nature Portfolio
2021
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oai:doaj.org-article:2390ab09b04a41c28245bac3ed08f2c92021-11-28T12:31:16ZSpatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions10.1038/s41467-021-26870-z2041-1723https://doaj.org/article/2390ab09b04a41c28245bac3ed08f2c92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26870-zhttps://doaj.org/toc/2041-1723Neuroblastoma is a devastating tumour in children. Here, the authors analyse multi-region patient samples using genomics and transcriptomics, revealing temporal and spatial heterogeneity and questioning the reliability of single-biopsy based diagnostics.Karin SchmelzJoern ToedlingMatt HuskaMaja C. CwiklaLouisa-Marie KruetzfeldtJutta ProbaPeter F. AmbrosInge M. AmbrosSengül BoralMarco LodriniCeline Y. ChenMartin BurkertDennis GuergenAnnabell SzymanskyKathy AstrahantseffAnnette KuenkeleKerstin HaaseMatthias FischerHedwig E. DeubzerFalk HertwigPatrick HundsdoerferAnton G. HenssenRoland F. SchwarzJohannes H. SchulteAngelika EggertNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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Science Q |
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Science Q Karin Schmelz Joern Toedling Matt Huska Maja C. Cwikla Louisa-Marie Kruetzfeldt Jutta Proba Peter F. Ambros Inge M. Ambros Sengül Boral Marco Lodrini Celine Y. Chen Martin Burkert Dennis Guergen Annabell Szymansky Kathy Astrahantseff Annette Kuenkele Kerstin Haase Matthias Fischer Hedwig E. Deubzer Falk Hertwig Patrick Hundsdoerfer Anton G. Henssen Roland F. Schwarz Johannes H. Schulte Angelika Eggert Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions |
| description |
Neuroblastoma is a devastating tumour in children. Here, the authors analyse multi-region patient samples using genomics and transcriptomics, revealing temporal and spatial heterogeneity and questioning the reliability of single-biopsy based diagnostics. |
| format |
article |
| author |
Karin Schmelz Joern Toedling Matt Huska Maja C. Cwikla Louisa-Marie Kruetzfeldt Jutta Proba Peter F. Ambros Inge M. Ambros Sengül Boral Marco Lodrini Celine Y. Chen Martin Burkert Dennis Guergen Annabell Szymansky Kathy Astrahantseff Annette Kuenkele Kerstin Haase Matthias Fischer Hedwig E. Deubzer Falk Hertwig Patrick Hundsdoerfer Anton G. Henssen Roland F. Schwarz Johannes H. Schulte Angelika Eggert |
| author_facet |
Karin Schmelz Joern Toedling Matt Huska Maja C. Cwikla Louisa-Marie Kruetzfeldt Jutta Proba Peter F. Ambros Inge M. Ambros Sengül Boral Marco Lodrini Celine Y. Chen Martin Burkert Dennis Guergen Annabell Szymansky Kathy Astrahantseff Annette Kuenkele Kerstin Haase Matthias Fischer Hedwig E. Deubzer Falk Hertwig Patrick Hundsdoerfer Anton G. Henssen Roland F. Schwarz Johannes H. Schulte Angelika Eggert |
| author_sort |
Karin Schmelz |
| title |
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions |
| title_short |
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions |
| title_full |
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions |
| title_fullStr |
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions |
| title_full_unstemmed |
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions |
| title_sort |
spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/2390ab09b04a41c28245bac3ed08f2c9 |
| work_keys_str_mv |
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1718407879819526144 |