Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects

Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects

Yan-Qiong Wu,1,* Shi-Yan Cheng,2,* Xian-Cheng Xu,1 Wen-Cui Li3 1Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China; 2Department of Respiratory Medicine, Suizhou Central Hospital, Hubei University of Medicine, Suizhou 441300, China; 3Department of Labora...

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Autores principales: Wu YQ, Cheng SY, Xu XC, Li WC
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
CD14
rs2569190
ischemic stroke
polymorphism
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/2391567193424c6db163ab80282717f3
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spelling oai:doaj.org-article:2391567193424c6db163ab80282717f32021-12-02T07:26:28ZAssociation between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects1178-2021https://doaj.org/article/2391567193424c6db163ab80282717f32018-12-01T00:00:00Zhttps://www.dovepress.com/association-between-cd14-rs2569190-cgtt-polymorphism-and-ischemic-stro-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yan-Qiong Wu,1,* Shi-Yan Cheng,2,* Xian-Cheng Xu,1 Wen-Cui Li3 1Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China; 2Department of Respiratory Medicine, Suizhou Central Hospital, Hubei University of Medicine, Suizhou 441300, China; 3Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China *These authors contributed equally to this work Introduction: Previous epidemiological studies have suggested that CD14 rs2569190 C>T polymorphism plays an important role in ischemic stroke (IS) risk, but the results were inconsistent. Therefore, we conducted a meta-analysis to determine the association between CD14 rs2569190 C>T polymorphism and IS susceptibility.Methods: Online databases were searched from inception up to July 1, 2018, for studies concerning CD14 rs2569190 C>T polymorphism and its association with IS susceptibility. ORs and corresponding 95% CIs were calculated in the genetic models of each polymorphism locus with Stata Version 14.0. Furthermore, heterogeneity, meta-regression, accumulative analyses, sensitivity analyses, and publication bias were examined.Results: Overall, 10 observed studies involving 5,277 subjects were included in this meta-analysis on CD14 rs2569190 C>T polymorphism. Generally, no significant associations were found between CD14 rs2569190 C>T polymorphism and IS risk (allele contrast of T vs C: OR =1.03, 95% CI =0.96–1.12, P=0.41, I2=27.8%; co-dominant models of CT vs CC: OR =1.01, 95% CI =0.81–1.25, P=0.95, I2=51.9%; co-dominant models of TT vs CC: OR =1.04, 95% CI =0.89–1.22, P=0.62, I2=25.1%; dominant model of CT + TT vs CC: OR =1.02, 95% CI =0.84–1.25, P=0.82, I2=51.4%; recessive model of TT vs CC + CT: OR =1.07, 95% CI =0.95–1.22, P=0.28, I2=0%), similar to the results in the subgroup analysis.Conclusion: The current evidence indicated that CD14 rs2569190 C>T polymorphism was not a critical risk factor for IS development. Keywords: CD14, ischemic stroke, polymorphism Wu YQCheng SYXu XCLi WCDove Medical PressarticleCD14rs2569190ischemic strokepolymorphismNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 47-55 (2018)
institution DOAJ
collection DOAJ
language EN
topic CD14
rs2569190
ischemic stroke
polymorphism
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle CD14
rs2569190
ischemic stroke
polymorphism
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Wu YQ
Cheng SY
Xu XC
Li WC
Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects
description Yan-Qiong Wu,1,* Shi-Yan Cheng,2,* Xian-Cheng Xu,1 Wen-Cui Li3 1Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China; 2Department of Respiratory Medicine, Suizhou Central Hospital, Hubei University of Medicine, Suizhou 441300, China; 3Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China *These authors contributed equally to this work Introduction: Previous epidemiological studies have suggested that CD14 rs2569190 C>T polymorphism plays an important role in ischemic stroke (IS) risk, but the results were inconsistent. Therefore, we conducted a meta-analysis to determine the association between CD14 rs2569190 C>T polymorphism and IS susceptibility.Methods: Online databases were searched from inception up to July 1, 2018, for studies concerning CD14 rs2569190 C>T polymorphism and its association with IS susceptibility. ORs and corresponding 95% CIs were calculated in the genetic models of each polymorphism locus with Stata Version 14.0. Furthermore, heterogeneity, meta-regression, accumulative analyses, sensitivity analyses, and publication bias were examined.Results: Overall, 10 observed studies involving 5,277 subjects were included in this meta-analysis on CD14 rs2569190 C>T polymorphism. Generally, no significant associations were found between CD14 rs2569190 C>T polymorphism and IS risk (allele contrast of T vs C: OR =1.03, 95% CI =0.96–1.12, P=0.41, I2=27.8%; co-dominant models of CT vs CC: OR =1.01, 95% CI =0.81–1.25, P=0.95, I2=51.9%; co-dominant models of TT vs CC: OR =1.04, 95% CI =0.89–1.22, P=0.62, I2=25.1%; dominant model of CT + TT vs CC: OR =1.02, 95% CI =0.84–1.25, P=0.82, I2=51.4%; recessive model of TT vs CC + CT: OR =1.07, 95% CI =0.95–1.22, P=0.28, I2=0%), similar to the results in the subgroup analysis.Conclusion: The current evidence indicated that CD14 rs2569190 C>T polymorphism was not a critical risk factor for IS development. Keywords: CD14, ischemic stroke, polymorphism 
format article
author Wu YQ
Cheng SY
Xu XC
Li WC
author_facet Wu YQ
Cheng SY
Xu XC
Li WC
author_sort Wu YQ
title Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects
title_short Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects
title_full Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects
title_fullStr Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects
title_full_unstemmed Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects
title_sort association between cd14 rs2569190 c>t polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/2391567193424c6db163ab80282717f3
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AT xuxc associationbetweencd14rs2569190cgttpolymorphismandischemicstrokesusceptibilityametaanalysisbasedon5277subjects
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