<italic toggle="yes">Bacillus subtilis</italic> Biofilms: a Matter of Individual Choice

ABSTRACT Bacillus subtilis has the capacity to choose between two mutually exclusive lifestyles: biofilm formation and flagellum-mediated swimming motility. Interestingly, this choice is made at the individual cell level, with bacterial cells in a population expressing genes required for biofilm for...

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Autores principales:	Bridgett K. Ryan-Payseur, Nancy E. Freitag
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	Bacillus subtilis SinR YmdB biofilm formation bistability Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2391c721adea436ca33486480f8bac8c
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spelling	oai:doaj.org-article:2391c721adea436ca33486480f8bac8c2021-11-15T15:52:20Z<italic toggle="yes">Bacillus subtilis</italic> Biofilms: a Matter of Individual Choice10.1128/mBio.02339-182150-7511https://doaj.org/article/2391c721adea436ca33486480f8bac8c2018-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02339-18https://doaj.org/toc/2150-7511ABSTRACT Bacillus subtilis has the capacity to choose between two mutually exclusive lifestyles: biofilm formation and flagellum-mediated swimming motility. Interestingly, this choice is made at the individual cell level, with bacterial cells in a population expressing genes required for biofilm formation or genes required for swimming motility but not both. A bistable switch controls the biofilm-versus-swimming decision, resulting in an evolutionarily favorable strategy known as “bet hedging” that ensures that subpopulations of bacteria continue to grow as conditions change and/or become unfavorable. In a recent issue of mBio, J. Kampf and colleagues (mBio 9:e01464-18, 2018, https://doi.org/10.1128/mBio.01464-18) reported the use of a combination of genetics and microfluidics to reveal that the interplay that occurs between the SinR and YmdB proteins underlies the B. subtilis choice between biofilm formation and swimming motility. Their report suggests that B. subtilis experiences selective pressure to form biofilms while maintaining reserve cell subpopulations with the capacity to swim away.Bridgett K. Ryan-PayseurNancy E. FreitagAmerican Society for MicrobiologyarticleBacillus subtilisSinRYmdBbiofilm formationbistabilityMicrobiologyQR1-502ENmBio, Vol 9, Iss 6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bacillus subtilis SinR YmdB biofilm formation bistability Microbiology QR1-502
spellingShingle	Bacillus subtilis SinR YmdB biofilm formation bistability Microbiology QR1-502 Bridgett K. Ryan-Payseur Nancy E. Freitag <italic toggle="yes">Bacillus subtilis</italic> Biofilms: a Matter of Individual Choice
description	ABSTRACT Bacillus subtilis has the capacity to choose between two mutually exclusive lifestyles: biofilm formation and flagellum-mediated swimming motility. Interestingly, this choice is made at the individual cell level, with bacterial cells in a population expressing genes required for biofilm formation or genes required for swimming motility but not both. A bistable switch controls the biofilm-versus-swimming decision, resulting in an evolutionarily favorable strategy known as “bet hedging” that ensures that subpopulations of bacteria continue to grow as conditions change and/or become unfavorable. In a recent issue of mBio, J. Kampf and colleagues (mBio 9:e01464-18, 2018, https://doi.org/10.1128/mBio.01464-18) reported the use of a combination of genetics and microfluidics to reveal that the interplay that occurs between the SinR and YmdB proteins underlies the B. subtilis choice between biofilm formation and swimming motility. Their report suggests that B. subtilis experiences selective pressure to form biofilms while maintaining reserve cell subpopulations with the capacity to swim away.
format	article
author	Bridgett K. Ryan-Payseur Nancy E. Freitag
author_facet	Bridgett K. Ryan-Payseur Nancy E. Freitag
author_sort	Bridgett K. Ryan-Payseur
title	<italic toggle="yes">Bacillus subtilis</italic> Biofilms: a Matter of Individual Choice
title_short	<italic toggle="yes">Bacillus subtilis</italic> Biofilms: a Matter of Individual Choice
title_full	<italic toggle="yes">Bacillus subtilis</italic> Biofilms: a Matter of Individual Choice
title_fullStr	<italic toggle="yes">Bacillus subtilis</italic> Biofilms: a Matter of Individual Choice
title_full_unstemmed	<italic toggle="yes">Bacillus subtilis</italic> Biofilms: a Matter of Individual Choice
title_sort	<italic toggle="yes">bacillus subtilis</italic> biofilms: a matter of individual choice
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/2391c721adea436ca33486480f8bac8c
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<italic toggle="yes">Bacillus subtilis</italic> Biofilms: a Matter of Individual Choice

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