Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome

Chandrasekaran et al. engineered the Drosophila circadian clock protein Cryptochrome (dCRY) to form the neutral semiquinone, which serves as a dark-state proxy. They find that the C-terminal tail of dCRY remains docked when the flavin ring is reduced but uncharged. dCRY His378 variants provide insig...

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Autores principales: Siddarth Chandrasekaran, Connor M. Schneps, Robert Dunleavy, Changfan Lin, Cristina C. DeOliveira, Abir Ganguly, Brian R. Crane
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/239433bfd7aa4c559db2c188b3ff245d
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