Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles

Abstract The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on the silver-silica core-shell nanoparticl...

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Autores principales:	Jessica Fernanda Affonso de Oliveira, Ângela Saito, Ariadne Tuckmantel Bido, Jörg Kobarg, Hubert Karl Stassen, Mateus Borba Cardoso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2395aed9728c484f8ade8dc485ae9408
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spelling	oai:doaj.org-article:2395aed9728c484f8ade8dc485ae94082021-12-02T11:40:30ZDefeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles10.1038/s41598-017-01209-12045-2322https://doaj.org/article/2395aed9728c484f8ade8dc485ae94082017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01209-1https://doaj.org/toc/2045-2322Abstract The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on the silver-silica core-shell nanoparticles surface to maximize biological responses. The obtained silver nanoparticles coated with mesoporous silica functionalized with ampicillin presented remarkable antimicrobial effects against susceptible and antibiotic-resistant Escherichia coli. In addition, these structures were not cell-death inducers and different steps of the mitotic cell cycle (prophase, anaphase and metaphase) were clearly identified. The superior biological results were attributed to a proper and tailored synthesis strategy.Jessica Fernanda Affonso de OliveiraÂngela SaitoAriadne Tuckmantel BidoJörg KobargHubert Karl StassenMateus Borba CardosoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jessica Fernanda Affonso de Oliveira Ângela Saito Ariadne Tuckmantel Bido Jörg Kobarg Hubert Karl Stassen Mateus Borba Cardoso Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles
description	Abstract The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on the silver-silica core-shell nanoparticles surface to maximize biological responses. The obtained silver nanoparticles coated with mesoporous silica functionalized with ampicillin presented remarkable antimicrobial effects against susceptible and antibiotic-resistant Escherichia coli. In addition, these structures were not cell-death inducers and different steps of the mitotic cell cycle (prophase, anaphase and metaphase) were clearly identified. The superior biological results were attributed to a proper and tailored synthesis strategy.
format	article
author	Jessica Fernanda Affonso de Oliveira Ângela Saito Ariadne Tuckmantel Bido Jörg Kobarg Hubert Karl Stassen Mateus Borba Cardoso
author_facet	Jessica Fernanda Affonso de Oliveira Ângela Saito Ariadne Tuckmantel Bido Jörg Kobarg Hubert Karl Stassen Mateus Borba Cardoso
author_sort	Jessica Fernanda Affonso de Oliveira
title	Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles
title_short	Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles
title_full	Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles
title_fullStr	Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles
title_full_unstemmed	Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles
title_sort	defeating bacterial resistance and preventing mammalian cells toxicity through rational design of antibiotic-functionalized nanoparticles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2395aed9728c484f8ade8dc485ae9408
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Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles

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