Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.

<h4>Background</h4>Urinary biomarkers for organ dysfunction could predict the outcomes of severe trauma patients. However, the use of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of trauma is not well studied.<h4>Objectives</h4>To evaluate the association...

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Autores principales:	Sakura Minami, Tomoki Doi, Takeru Abe, Ichiro Takeuchi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2398426b1ccb495a9a447608249b1f56
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spelling	oai:doaj.org-article:2398426b1ccb495a9a447608249b1f562021-12-02T20:11:22ZNeutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.1932-620310.1371/journal.pone.0251319https://doaj.org/article/2398426b1ccb495a9a447608249b1f562021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251319https://doaj.org/toc/1932-6203<h4>Background</h4>Urinary biomarkers for organ dysfunction could predict the outcomes of severe trauma patients. However, the use of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of trauma is not well studied.<h4>Objectives</h4>To evaluate the association between the short-term prognosis of trauma patients and NGAL levels.<h4>Methods</h4>We conducted a single center study and compared predictive performances between NGAL levels and the trauma severity.<h4>Results</h4>A total of 104 patients were included in the study. Patients were divided into two groups based on ISS score of 16. There was no significant difference in patient characteristics based on trauma severity. However, the lactate level was significantly higher in the more severe group. There was a significant association between urinary NGAL levels and trauma severity indicators, such as intensive care unit stay (ICU) (p = 0.005) and emergency care unit (ECU) stay (p = 0.049). In addition, receiver operating curve analysis showed that as a predictor, NGAL could be used for detecting severity with moderate precision, especially for short-term outcomes (specificity 70.6 for ICU and 69.0 for ECU stay).<h4>Conclusion</h4>In this study, we revealed that the level of NGAL could predict the degree of invasiveness in trauma patients with moderate precision and estimate the duration of treatment during the acute phase. It is necessary to examine the validity of the findings of this study using a prospective, cohort, and multi-center collaborative study design.Sakura MinamiTomoki DoiTakeru AbeIchiro TakeuchiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251319 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sakura Minami Tomoki Doi Takeru Abe Ichiro Takeuchi Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
description	<h4>Background</h4>Urinary biomarkers for organ dysfunction could predict the outcomes of severe trauma patients. However, the use of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of trauma is not well studied.<h4>Objectives</h4>To evaluate the association between the short-term prognosis of trauma patients and NGAL levels.<h4>Methods</h4>We conducted a single center study and compared predictive performances between NGAL levels and the trauma severity.<h4>Results</h4>A total of 104 patients were included in the study. Patients were divided into two groups based on ISS score of 16. There was no significant difference in patient characteristics based on trauma severity. However, the lactate level was significantly higher in the more severe group. There was a significant association between urinary NGAL levels and trauma severity indicators, such as intensive care unit stay (ICU) (p = 0.005) and emergency care unit (ECU) stay (p = 0.049). In addition, receiver operating curve analysis showed that as a predictor, NGAL could be used for detecting severity with moderate precision, especially for short-term outcomes (specificity 70.6 for ICU and 69.0 for ECU stay).<h4>Conclusion</h4>In this study, we revealed that the level of NGAL could predict the degree of invasiveness in trauma patients with moderate precision and estimate the duration of treatment during the acute phase. It is necessary to examine the validity of the findings of this study using a prospective, cohort, and multi-center collaborative study design.
format	article
author	Sakura Minami Tomoki Doi Takeru Abe Ichiro Takeuchi
author_facet	Sakura Minami Tomoki Doi Takeru Abe Ichiro Takeuchi
author_sort	Sakura Minami
title	Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
title_short	Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
title_full	Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
title_fullStr	Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
title_full_unstemmed	Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
title_sort	neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: a single-center observational study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2398426b1ccb495a9a447608249b1f56
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Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.

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