Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.

<h4>Background</h4>Urinary biomarkers for organ dysfunction could predict the outcomes of severe trauma patients. However, the use of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of trauma is not well studied.<h4>Objectives</h4>To evaluate the association...

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Autores principales: Sakura Minami, Tomoki Doi, Takeru Abe, Ichiro Takeuchi
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:2398426b1ccb495a9a447608249b1f562021-12-02T20:11:22ZNeutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.1932-620310.1371/journal.pone.0251319https://doaj.org/article/2398426b1ccb495a9a447608249b1f562021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251319https://doaj.org/toc/1932-6203<h4>Background</h4>Urinary biomarkers for organ dysfunction could predict the outcomes of severe trauma patients. However, the use of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of trauma is not well studied.<h4>Objectives</h4>To evaluate the association between the short-term prognosis of trauma patients and NGAL levels.<h4>Methods</h4>We conducted a single center study and compared predictive performances between NGAL levels and the trauma severity.<h4>Results</h4>A total of 104 patients were included in the study. Patients were divided into two groups based on ISS score of 16. There was no significant difference in patient characteristics based on trauma severity. However, the lactate level was significantly higher in the more severe group. There was a significant association between urinary NGAL levels and trauma severity indicators, such as intensive care unit stay (ICU) (p = 0.005) and emergency care unit (ECU) stay (p = 0.049). In addition, receiver operating curve analysis showed that as a predictor, NGAL could be used for detecting severity with moderate precision, especially for short-term outcomes (specificity 70.6 for ICU and 69.0 for ECU stay).<h4>Conclusion</h4>In this study, we revealed that the level of NGAL could predict the degree of invasiveness in trauma patients with moderate precision and estimate the duration of treatment during the acute phase. It is necessary to examine the validity of the findings of this study using a prospective, cohort, and multi-center collaborative study design.Sakura MinamiTomoki DoiTakeru AbeIchiro TakeuchiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251319 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Sakura Minami
Tomoki Doi
Takeru Abe
Ichiro Takeuchi
Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
description <h4>Background</h4>Urinary biomarkers for organ dysfunction could predict the outcomes of severe trauma patients. However, the use of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of trauma is not well studied.<h4>Objectives</h4>To evaluate the association between the short-term prognosis of trauma patients and NGAL levels.<h4>Methods</h4>We conducted a single center study and compared predictive performances between NGAL levels and the trauma severity.<h4>Results</h4>A total of 104 patients were included in the study. Patients were divided into two groups based on ISS score of 16. There was no significant difference in patient characteristics based on trauma severity. However, the lactate level was significantly higher in the more severe group. There was a significant association between urinary NGAL levels and trauma severity indicators, such as intensive care unit stay (ICU) (p = 0.005) and emergency care unit (ECU) stay (p = 0.049). In addition, receiver operating curve analysis showed that as a predictor, NGAL could be used for detecting severity with moderate precision, especially for short-term outcomes (specificity 70.6 for ICU and 69.0 for ECU stay).<h4>Conclusion</h4>In this study, we revealed that the level of NGAL could predict the degree of invasiveness in trauma patients with moderate precision and estimate the duration of treatment during the acute phase. It is necessary to examine the validity of the findings of this study using a prospective, cohort, and multi-center collaborative study design.
format article
author Sakura Minami
Tomoki Doi
Takeru Abe
Ichiro Takeuchi
author_facet Sakura Minami
Tomoki Doi
Takeru Abe
Ichiro Takeuchi
author_sort Sakura Minami
title Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
title_short Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
title_full Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
title_fullStr Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
title_full_unstemmed Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.
title_sort neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: a single-center observational study.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/2398426b1ccb495a9a447608249b1f56
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AT takeruabe neutrophilgelatinaseassociatedlipocalinasabiomarkerforshorttermoutcomesamongtraumapatientsasinglecenterobservationalstudy
AT ichirotakeuchi neutrophilgelatinaseassociatedlipocalinasabiomarkerforshorttermoutcomesamongtraumapatientsasinglecenterobservationalstudy
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