Comparative Study between Intranasal Injection of Botulinum Toxin-A and Combined Intranasal Medical Treatment for Allergic Rhinitis

Background: Allergic rhinitis is one of the most common diseases, with no consensus on its ideal treatment. Botulinum Toxin-A was proposed to be an effective treatment. Aim of the work: To estimate the outcome of intranasal injection of Botulinum Toxin-A [BTX-A] as a sole therapy for allergic rhin...

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Main Authors:	Nabil Sarhan, Mohamed Fathallah, Ashraf Wahba, Ahmed Alwan
Format:	article
Language:	EN
Published:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Subjects:	allergic rhinitis botulinum toxin-a intranasal injection medical treatment score for allergic rhinitis Medicine (General) R5-920
Online Access:	https://doaj.org/article/2399b5b2e3604e7ea2aaf4650e8ab23a
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spelling	oai:doaj.org-article:2399b5b2e3604e7ea2aaf4650e8ab23a2021-12-02T10:38:27ZComparative Study between Intranasal Injection of Botulinum Toxin-A and Combined Intranasal Medical Treatment for Allergic Rhinitis2636-41742682-378010.21608/ijma.2020.26878.1113https://doaj.org/article/2399b5b2e3604e7ea2aaf4650e8ab23a2020-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_97557_49e0d9b4d8de32cf2820631a299a87e0.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Allergic rhinitis is one of the most common diseases, with no consensus on its ideal treatment. Botulinum Toxin-A was proposed to be an effective treatment. Aim of the work: To estimate the outcome of intranasal injection of Botulinum Toxin-A [BTX-A] as a sole therapy for allergic rhinitis. Patients and Methods:Ninty patients with classic symptoms of allergic rhinitis were clinically evaluated and asked to complete the score for allergic rhinitis [SFAR] questionnaire using cutoff at >8 as diagnostic AR. Two blood samples [venous] and nasal smears were obtained at the beginning of the study and at the end of 12-weeks after initiation of therapy for estimation of human immunoglobulin E [IgE] and eosinophilia grading. Control group included patients who chose to receive combined medical treatment. BTX-A, 2.5 units were injected intranasally, under 0o rigid telescope guidance. Study outcome was the treatment success rate at the end of 12-w follow-up period. Results: Intranasal BTX-A injection provided significantly maintained relieve of allergic rhinitis manifestations especially for running nose than combination therapy. The treatment success rate of 1.9 versus 0.7 item/patient in study versus control group with significant difference in favor of BTX-A injection. Serum IgE levels and eosinophilia grades were significantly lower in control patients. Patients' satisfaction grading was significantly more with BTX-A injection. Conclusion: Intranasal BTX injection could be a safe and effective sole therapeutic modality for patients with long-lasting ARNabil SarhanMohamed FathallahAshraf WahbaAhmed AlwanAl-Azhar University, Faculty of Medicine (Damietta)articleallergic rhinitisbotulinum toxin-aintranasal injectionmedical treatmentscore for allergic rhinitisMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 3, Pp 590-598 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	allergic rhinitis botulinum toxin-a intranasal injection medical treatment score for allergic rhinitis Medicine (General) R5-920
spellingShingle	allergic rhinitis botulinum toxin-a intranasal injection medical treatment score for allergic rhinitis Medicine (General) R5-920 Nabil Sarhan Mohamed Fathallah Ashraf Wahba Ahmed Alwan Comparative Study between Intranasal Injection of Botulinum Toxin-A and Combined Intranasal Medical Treatment for Allergic Rhinitis
description	Background: Allergic rhinitis is one of the most common diseases, with no consensus on its ideal treatment. Botulinum Toxin-A was proposed to be an effective treatment. Aim of the work: To estimate the outcome of intranasal injection of Botulinum Toxin-A [BTX-A] as a sole therapy for allergic rhinitis. Patients and Methods:Ninty patients with classic symptoms of allergic rhinitis were clinically evaluated and asked to complete the score for allergic rhinitis [SFAR] questionnaire using cutoff at >8 as diagnostic AR. Two blood samples [venous] and nasal smears were obtained at the beginning of the study and at the end of 12-weeks after initiation of therapy for estimation of human immunoglobulin E [IgE] and eosinophilia grading. Control group included patients who chose to receive combined medical treatment. BTX-A, 2.5 units were injected intranasally, under 0o rigid telescope guidance. Study outcome was the treatment success rate at the end of 12-w follow-up period. Results: Intranasal BTX-A injection provided significantly maintained relieve of allergic rhinitis manifestations especially for running nose than combination therapy. The treatment success rate of 1.9 versus 0.7 item/patient in study versus control group with significant difference in favor of BTX-A injection. Serum IgE levels and eosinophilia grades were significantly lower in control patients. Patients' satisfaction grading was significantly more with BTX-A injection. Conclusion: Intranasal BTX injection could be a safe and effective sole therapeutic modality for patients with long-lasting AR
format	article
author	Nabil Sarhan Mohamed Fathallah Ashraf Wahba Ahmed Alwan
author_facet	Nabil Sarhan Mohamed Fathallah Ashraf Wahba Ahmed Alwan
author_sort	Nabil Sarhan
title	Comparative Study between Intranasal Injection of Botulinum Toxin-A and Combined Intranasal Medical Treatment for Allergic Rhinitis
title_short	Comparative Study between Intranasal Injection of Botulinum Toxin-A and Combined Intranasal Medical Treatment for Allergic Rhinitis
title_full	Comparative Study between Intranasal Injection of Botulinum Toxin-A and Combined Intranasal Medical Treatment for Allergic Rhinitis
title_fullStr	Comparative Study between Intranasal Injection of Botulinum Toxin-A and Combined Intranasal Medical Treatment for Allergic Rhinitis
title_full_unstemmed	Comparative Study between Intranasal Injection of Botulinum Toxin-A and Combined Intranasal Medical Treatment for Allergic Rhinitis
title_sort	comparative study between intranasal injection of botulinum toxin-a and combined intranasal medical treatment for allergic rhinitis
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/2399b5b2e3604e7ea2aaf4650e8ab23a
work_keys_str_mv	AT nabilsarhan comparativestudybetweenintranasalinjectionofbotulinumtoxinaandcombinedintranasalmedicaltreatmentforallergicrhinitis AT mohamedfathallah comparativestudybetweenintranasalinjectionofbotulinumtoxinaandcombinedintranasalmedicaltreatmentforallergicrhinitis AT ashrafwahba comparativestudybetweenintranasalinjectionofbotulinumtoxinaandcombinedintranasalmedicaltreatmentforallergicrhinitis AT ahmedalwan comparativestudybetweenintranasalinjectionofbotulinumtoxinaandcombinedintranasalmedicaltreatmentforallergicrhinitis
_version_	1718396868560420864

Comparative Study between Intranasal Injection of Botulinum Toxin-A and Combined Intranasal Medical Treatment for Allergic Rhinitis

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