Nicotianamine, a novel enhancer of rice iron bioavailability to humans.

<h4>Background</h4>Polished rice is a staple food for over 50% of the world's population, but contains little bioavailable iron (Fe) to meet human needs. Thus, biofortifying the rice grain with novel promoters or enhancers of Fe utilization would be one of the most effective strateg...

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Autores principales:	Luqing Zheng, Zhiqiang Cheng, Chunxiang Ai, Xinhang Jiang, Xiaoshu Bei, Ye Zheng, Raymond P Glahn, Ross M Welch, Dennis D Miller, Xin Gen Lei, Huixia Shou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2399e4528cb44762a718f75439d854da
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spelling	oai:doaj.org-article:2399e4528cb44762a718f75439d854da2021-11-25T06:24:30ZNicotianamine, a novel enhancer of rice iron bioavailability to humans.1932-620310.1371/journal.pone.0010190https://doaj.org/article/2399e4528cb44762a718f75439d854da2010-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20419136/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Polished rice is a staple food for over 50% of the world's population, but contains little bioavailable iron (Fe) to meet human needs. Thus, biofortifying the rice grain with novel promoters or enhancers of Fe utilization would be one of the most effective strategies to prevent the high prevalence of Fe deficiency and iron deficiency anemia in the developing world.<h4>Methodology/principal findings</h4>We transformed an elite rice line cultivated in Southern China with the rice nicotianamine synthase gene (OsNAS1) fused to a rice glutelin promoter. Endosperm overexpression of OsNAS1 resulted in a significant increase in nicotianamine (NA) concentrations in both unpolished and polished grain. Bioavailability of Fe from the high NA grain, as measured by ferritin synthesis in an in vitro Caco-2 cell model that simulates the human digestive system, was twice as much as that of the control line. When added at 1:1 molar ratio to ferrous Fe in the cell system, NA was twice as effective when compared to ascorbic acid (one of the most potent known enhancers of Fe bioavailability) in promoting more ferritin synthesis.<h4>Conclusions</h4>Our data demonstrated that NA is a novel and effective promoter of iron utilization. Biofortifying polished rice with this compound has great potential in combating global human iron deficiency in people dependent on rice for their sustenance.Luqing ZhengZhiqiang ChengChunxiang AiXinhang JiangXiaoshu BeiYe ZhengRaymond P GlahnRoss M WelchDennis D MillerXin Gen LeiHuixia ShouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 4, p e10190 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luqing Zheng Zhiqiang Cheng Chunxiang Ai Xinhang Jiang Xiaoshu Bei Ye Zheng Raymond P Glahn Ross M Welch Dennis D Miller Xin Gen Lei Huixia Shou Nicotianamine, a novel enhancer of rice iron bioavailability to humans.
description	<h4>Background</h4>Polished rice is a staple food for over 50% of the world's population, but contains little bioavailable iron (Fe) to meet human needs. Thus, biofortifying the rice grain with novel promoters or enhancers of Fe utilization would be one of the most effective strategies to prevent the high prevalence of Fe deficiency and iron deficiency anemia in the developing world.<h4>Methodology/principal findings</h4>We transformed an elite rice line cultivated in Southern China with the rice nicotianamine synthase gene (OsNAS1) fused to a rice glutelin promoter. Endosperm overexpression of OsNAS1 resulted in a significant increase in nicotianamine (NA) concentrations in both unpolished and polished grain. Bioavailability of Fe from the high NA grain, as measured by ferritin synthesis in an in vitro Caco-2 cell model that simulates the human digestive system, was twice as much as that of the control line. When added at 1:1 molar ratio to ferrous Fe in the cell system, NA was twice as effective when compared to ascorbic acid (one of the most potent known enhancers of Fe bioavailability) in promoting more ferritin synthesis.<h4>Conclusions</h4>Our data demonstrated that NA is a novel and effective promoter of iron utilization. Biofortifying polished rice with this compound has great potential in combating global human iron deficiency in people dependent on rice for their sustenance.
format	article
author	Luqing Zheng Zhiqiang Cheng Chunxiang Ai Xinhang Jiang Xiaoshu Bei Ye Zheng Raymond P Glahn Ross M Welch Dennis D Miller Xin Gen Lei Huixia Shou
author_facet	Luqing Zheng Zhiqiang Cheng Chunxiang Ai Xinhang Jiang Xiaoshu Bei Ye Zheng Raymond P Glahn Ross M Welch Dennis D Miller Xin Gen Lei Huixia Shou
author_sort	Luqing Zheng
title	Nicotianamine, a novel enhancer of rice iron bioavailability to humans.
title_short	Nicotianamine, a novel enhancer of rice iron bioavailability to humans.
title_full	Nicotianamine, a novel enhancer of rice iron bioavailability to humans.
title_fullStr	Nicotianamine, a novel enhancer of rice iron bioavailability to humans.
title_full_unstemmed	Nicotianamine, a novel enhancer of rice iron bioavailability to humans.
title_sort	nicotianamine, a novel enhancer of rice iron bioavailability to humans.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/2399e4528cb44762a718f75439d854da
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Nicotianamine, a novel enhancer of rice iron bioavailability to humans.

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