Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

Fiolopodia are involved in cell migration and their attachment to the ECM is mediated by integrin receptors. Here the authors show that myosin X induced filipodia adhesion to fibronectin requires activity of myosin IIA at the filopodium base and formin at the tip to support force transmission throug...

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Autores principales:	N. O. Alieva, A. K. Efremov, S. Hu, D. Oh, Z. Chen, M. Natarajan, H. T. Ong, A. Jégou, G. Romet-Lemonne, J. T. Groves, M. P. Sheetz, J. Yan, A. D. Bershadsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/239c9ca67f0f454d9d9ef6109dc7854c
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spelling	oai:doaj.org-article:239c9ca67f0f454d9d9ef6109dc7854c2021-12-02T16:58:01ZMyosin IIA and formin dependent mechanosensitivity of filopodia adhesion10.1038/s41467-019-10964-w2041-1723https://doaj.org/article/239c9ca67f0f454d9d9ef6109dc7854c2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10964-whttps://doaj.org/toc/2041-1723Fiolopodia are involved in cell migration and their attachment to the ECM is mediated by integrin receptors. Here the authors show that myosin X induced filipodia adhesion to fibronectin requires activity of myosin IIA at the filopodium base and formin at the tip to support force transmission through the actin core.N. O. AlievaA. K. EfremovS. HuD. OhZ. ChenM. NatarajanH. T. OngA. JégouG. Romet-LemonneJ. T. GrovesM. P. SheetzJ. YanA. D. BershadskyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q N. O. Alieva A. K. Efremov S. Hu D. Oh Z. Chen M. Natarajan H. T. Ong A. Jégou G. Romet-Lemonne J. T. Groves M. P. Sheetz J. Yan A. D. Bershadsky Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion
description	Fiolopodia are involved in cell migration and their attachment to the ECM is mediated by integrin receptors. Here the authors show that myosin X induced filipodia adhesion to fibronectin requires activity of myosin IIA at the filopodium base and formin at the tip to support force transmission through the actin core.
format	article
author	N. O. Alieva A. K. Efremov S. Hu D. Oh Z. Chen M. Natarajan H. T. Ong A. Jégou G. Romet-Lemonne J. T. Groves M. P. Sheetz J. Yan A. D. Bershadsky
author_facet	N. O. Alieva A. K. Efremov S. Hu D. Oh Z. Chen M. Natarajan H. T. Ong A. Jégou G. Romet-Lemonne J. T. Groves M. P. Sheetz J. Yan A. D. Bershadsky
author_sort	N. O. Alieva
title	Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion
title_short	Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion
title_full	Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion
title_fullStr	Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion
title_full_unstemmed	Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion
title_sort	myosin iia and formin dependent mechanosensitivity of filopodia adhesion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/239c9ca67f0f454d9d9ef6109dc7854c
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Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

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