The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function

Jie Han,* Xiaona Wang,* Ping Ye, Ruihua Cao, Xu Yang, Wenkai Xiao, Yun Zhang, Yongyi Bai, Hongmei Wu Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China *These authors contributed equally to this work Objectives: Despite growing...

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Autores principales:	Han J, Wang X, Ye P, Cao R, Yang X, Xiao W, Zhang Y, Bai Y, Wu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	epidemiology arterial stiffness chronic kidney disease predictive value Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/239ff4b1ec564ac3b0d796585cdcde8f
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spelling	oai:doaj.org-article:239ff4b1ec564ac3b0d796585cdcde8f2021-12-02T09:03:08ZThe predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function1178-1998https://doaj.org/article/239ff4b1ec564ac3b0d796585cdcde8f2016-08-01T00:00:00Zhttps://www.dovepress.com/the-predictive-value-of-arterial-stiffness-on-major-adverse-cardiovasc-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jie Han,* Xiaona Wang,* Ping Ye, Ruihua Cao, Xu Yang, Wenkai Xiao, Yun Zhang, Yongyi Bai, Hongmei Wu Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China *These authors contributed equally to this work Objectives: Despite growing evidence that arterial stiffness has important predictive value for cardiovascular disease in patients with advanced stages of chronic kidney disease, the predictive significance of arterial stiffness in individuals with mildly impaired renal function has not been established. The aim of this study was to evaluate the predictive value of arterial stiffness on cardiovascular disease in this specific population. Materials and methods: We analyzed measurements of arterial stiffness (carotid–femoral pulse-wave velocity [cf-PWV]) and the incidence of major adverse cardiovascular events (MACEs) in 1,499 subjects from a 4.8-year longitudinal study. Results: A multivariate Cox proportional-hazard regression analysis showed that in individuals with normal renal function (estimated glomerular filtration rate [eGFR] ≥90 mL/min/1.73 m2), the baseline cf-PWV was not associated with occurrence of MACEs (hazard ratio 1.398, 95% confidence interval 0.748–2.613; P=0.293). In individuals with mildly impaired renal function (eGFR <90 mL/min/1.73 m2), a higher baseline cf-PWV level was associated with a higher risk of MACEs (hazard ratio 2.334, 95% confidence interval 1.082–5.036; P=0.031). Conclusion: Arterial stiffness is a moderate and independent predictive factor for MACEs in individuals with mildly impaired renal function (eGFR <90 mL/min/1.73 m2). Keywords: epidemiology, arterial stiffness, impaired renal function, predictive value, MACEsHan JWang XYe PCao RYang XXiao WZhang YBai YWu HDove Medical Pressarticleepidemiologyarterial stiffnesschronic kidney diseasepredictive valueGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 1175-1181 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	epidemiology arterial stiffness chronic kidney disease predictive value Geriatrics RC952-954.6
spellingShingle	epidemiology arterial stiffness chronic kidney disease predictive value Geriatrics RC952-954.6 Han J Wang X Ye P Cao R Yang X Xiao W Zhang Y Bai Y Wu H The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function
description	Jie Han,* Xiaona Wang,* Ping Ye, Ruihua Cao, Xu Yang, Wenkai Xiao, Yun Zhang, Yongyi Bai, Hongmei Wu Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China *These authors contributed equally to this work Objectives: Despite growing evidence that arterial stiffness has important predictive value for cardiovascular disease in patients with advanced stages of chronic kidney disease, the predictive significance of arterial stiffness in individuals with mildly impaired renal function has not been established. The aim of this study was to evaluate the predictive value of arterial stiffness on cardiovascular disease in this specific population. Materials and methods: We analyzed measurements of arterial stiffness (carotid–femoral pulse-wave velocity [cf-PWV]) and the incidence of major adverse cardiovascular events (MACEs) in 1,499 subjects from a 4.8-year longitudinal study. Results: A multivariate Cox proportional-hazard regression analysis showed that in individuals with normal renal function (estimated glomerular filtration rate [eGFR] ≥90 mL/min/1.73 m2), the baseline cf-PWV was not associated with occurrence of MACEs (hazard ratio 1.398, 95% confidence interval 0.748–2.613; P=0.293). In individuals with mildly impaired renal function (eGFR <90 mL/min/1.73 m2), a higher baseline cf-PWV level was associated with a higher risk of MACEs (hazard ratio 2.334, 95% confidence interval 1.082–5.036; P=0.031). Conclusion: Arterial stiffness is a moderate and independent predictive factor for MACEs in individuals with mildly impaired renal function (eGFR <90 mL/min/1.73 m2). Keywords: epidemiology, arterial stiffness, impaired renal function, predictive value, MACEs
format	article
author	Han J Wang X Ye P Cao R Yang X Xiao W Zhang Y Bai Y Wu H
author_facet	Han J Wang X Ye P Cao R Yang X Xiao W Zhang Y Bai Y Wu H
author_sort	Han J
title	The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function
title_short	The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function
title_full	The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function
title_fullStr	The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function
title_full_unstemmed	The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function
title_sort	predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/239ff4b1ec564ac3b0d796585cdcde8f
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The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function

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