Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control

Abstract Response to antihypertensive drugs in patients with chronic kidney disease (CKD) has great interindividual variability. Adrenomedullin (ADM) is produced abundantly in hypertension, but clearance is very rapid. Mid-regional proADM (MR-proADM) produced from an ADM precursor is considered a su...

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Autores principales:	Motoshi Iwao, Ryota Tanaka, Yosuke Suzuki, Takeshi Nakata, Kohei Aoki, Akihiro Fukuda, Naoya Fukunaga, Ryosuke Tatsuta, Keiko Ohno, Hirotaka Shibata, Hiroki Itoh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23a40a1458d841bbb79e367f4c2dbd8c
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spelling	oai:doaj.org-article:23a40a1458d841bbb79e367f4c2dbd8c2021-11-14T12:22:13ZAssociation between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control10.1038/s41598-021-01403-22045-2322https://doaj.org/article/23a40a1458d841bbb79e367f4c2dbd8c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01403-2https://doaj.org/toc/2045-2322Abstract Response to antihypertensive drugs in patients with chronic kidney disease (CKD) has great interindividual variability. Adrenomedullin (ADM) is produced abundantly in hypertension, but clearance is very rapid. Mid-regional proADM (MR-proADM) produced from an ADM precursor is considered a surrogate biomarker for quantification of ADM. We investigated the association of MR-proADM with antihypertensive resistance in CKD patients with poor blood pressure (BP) control. This cross-sectional study analyzed 33 CKD patients with poor BP control defined as failure to achieve target BP despite at least two classes of antihypertensive drugs. Treatment intensity score was calculated to facilitate comparability of antihypertensive regimens across subjects taking different drugs. Plasma MR-proADM concentration was measured using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Plasma MR-proADM concentration correlated with estimated glomerular filtration rate (eGFR) (r = − 0.777, p < 0.001). Treatment intensity score correlated positively with plasma MR-proADM concentration (r = 0.355, p = 0.043), and the correlation was further enhanced after correction by weight (r = 0.538, p = 0.001). Single and multiple regression analysis identified MR-proADM concentration (p = 0.005) as independently associated with weight-corrected treatment intensity score. MR-proADM may be useful as a biomarker to determine the therapeutic intensity of antihypertensive drugs in CKD patients with poor BP control.Motoshi IwaoRyota TanakaYosuke SuzukiTakeshi NakataKohei AokiAkihiro FukudaNaoya FukunagaRyosuke TatsutaKeiko OhnoHirotaka ShibataHiroki ItohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Motoshi Iwao Ryota Tanaka Yosuke Suzuki Takeshi Nakata Kohei Aoki Akihiro Fukuda Naoya Fukunaga Ryosuke Tatsuta Keiko Ohno Hirotaka Shibata Hiroki Itoh Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control
description	Abstract Response to antihypertensive drugs in patients with chronic kidney disease (CKD) has great interindividual variability. Adrenomedullin (ADM) is produced abundantly in hypertension, but clearance is very rapid. Mid-regional proADM (MR-proADM) produced from an ADM precursor is considered a surrogate biomarker for quantification of ADM. We investigated the association of MR-proADM with antihypertensive resistance in CKD patients with poor blood pressure (BP) control. This cross-sectional study analyzed 33 CKD patients with poor BP control defined as failure to achieve target BP despite at least two classes of antihypertensive drugs. Treatment intensity score was calculated to facilitate comparability of antihypertensive regimens across subjects taking different drugs. Plasma MR-proADM concentration was measured using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Plasma MR-proADM concentration correlated with estimated glomerular filtration rate (eGFR) (r = − 0.777, p < 0.001). Treatment intensity score correlated positively with plasma MR-proADM concentration (r = 0.355, p = 0.043), and the correlation was further enhanced after correction by weight (r = 0.538, p = 0.001). Single and multiple regression analysis identified MR-proADM concentration (p = 0.005) as independently associated with weight-corrected treatment intensity score. MR-proADM may be useful as a biomarker to determine the therapeutic intensity of antihypertensive drugs in CKD patients with poor BP control.
format	article
author	Motoshi Iwao Ryota Tanaka Yosuke Suzuki Takeshi Nakata Kohei Aoki Akihiro Fukuda Naoya Fukunaga Ryosuke Tatsuta Keiko Ohno Hirotaka Shibata Hiroki Itoh
author_facet	Motoshi Iwao Ryota Tanaka Yosuke Suzuki Takeshi Nakata Kohei Aoki Akihiro Fukuda Naoya Fukunaga Ryosuke Tatsuta Keiko Ohno Hirotaka Shibata Hiroki Itoh
author_sort	Motoshi Iwao
title	Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control
title_short	Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control
title_full	Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control
title_fullStr	Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control
title_full_unstemmed	Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control
title_sort	association between mr-proadm concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23a40a1458d841bbb79e367f4c2dbd8c
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Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control

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