Arginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
Studies have demonstrated that polymorphic variants of arginase 1 gene (<i>ARG1</i>) are involved in human diseases, such as coronary heart disease, hypertension, and diabetes. Our study aimed to investigate the association between <i>ARG1</i> rs2781666 single nucleotide poly...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/23a6679ea2ac485587107b8f03fa1771 |
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| Sumario: | Studies have demonstrated that polymorphic variants of arginase 1 gene (<i>ARG1</i>) are involved in human diseases, such as coronary heart disease, hypertension, and diabetes. Our study aimed to investigate the association between <i>ARG1</i> rs2781666 single nucleotide polymorphism (SNP) and diabetic retinopathy (DR) in type 2 diabetes (T2DM) patients. Polymorphism was genotyped in 740 T2DM patients and 400 healthy individuals. A significant difference in the genotype distribution was observed between the patients and the controls. The T allele and TT genotype were associated with an increased risk of T2DM (OR 1.4, 95% CI 1.14–1.72, <i>p</i> = 0.001 and OR 2.16, 95% CI 1.23–3.80, <i>p</i> = 0.007, respectively). When the T2DM subjects were stratified into DR+ and DR− subgroups, the T allele and TT genotype frequencies were significantly higher in the DR+ group compared to the DR− group, demonstrating OR 1.68 (1.33–2.12), <i>p</i> < 0.0001 and OR 2.39 (1.36–4.18), <i>p</i> = 0.002, respectively. Logistic regression analysis was applied to determine the interaction between the <i>ARG1</i> genotypes and other risk factors. Only <i>ARG1</i> rs2781666 SNP was a significant risk predictor of DR (<i>p</i> = 0.003). In conclusion, this is the first report discussing the effect of <i>ARG1</i> polymorphism on the microvascular complications that are associated with diabetes. Our findings demonstrate that <i>ARG1</i> rs2781666 SNP is significantly associated with an increased susceptibility to DR in T2DM patients. |
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