Arginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients

Studies have demonstrated that polymorphic variants of arginase 1 gene (<i>ARG1</i>) are involved in human diseases, such as coronary heart disease, hypertension, and diabetes. Our study aimed to investigate the association between <i>ARG1</i> rs2781666 single nucleotide poly...

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Autores principales:	Monika Buraczynska, Izabela Zakrocka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arginase 1 diabetic retinopathy single nucleotide polymorphism rs2781666 genotyping Medicine R
Acceso en línea:	https://doaj.org/article/23a6679ea2ac485587107b8f03fa1771
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spelling	oai:doaj.org-article:23a6679ea2ac485587107b8f03fa17712021-11-25T18:02:30ZArginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients10.3390/jcm102254072077-0383https://doaj.org/article/23a6679ea2ac485587107b8f03fa17712021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5407https://doaj.org/toc/2077-0383Studies have demonstrated that polymorphic variants of arginase 1 gene (<i>ARG1</i>) are involved in human diseases, such as coronary heart disease, hypertension, and diabetes. Our study aimed to investigate the association between <i>ARG1</i> rs2781666 single nucleotide polymorphism (SNP) and diabetic retinopathy (DR) in type 2 diabetes (T2DM) patients. Polymorphism was genotyped in 740 T2DM patients and 400 healthy individuals. A significant difference in the genotype distribution was observed between the patients and the controls. The T allele and TT genotype were associated with an increased risk of T2DM (OR 1.4, 95% CI 1.14–1.72, <i>p</i> = 0.001 and OR 2.16, 95% CI 1.23–3.80, <i>p</i> = 0.007, respectively). When the T2DM subjects were stratified into DR+ and DR− subgroups, the T allele and TT genotype frequencies were significantly higher in the DR+ group compared to the DR− group, demonstrating OR 1.68 (1.33–2.12), <i>p</i> < 0.0001 and OR 2.39 (1.36–4.18), <i>p</i> = 0.002, respectively. Logistic regression analysis was applied to determine the interaction between the <i>ARG1</i> genotypes and other risk factors. Only <i>ARG1</i> rs2781666 SNP was a significant risk predictor of DR (<i>p</i> = 0.003). In conclusion, this is the first report discussing the effect of <i>ARG1</i> polymorphism on the microvascular complications that are associated with diabetes. Our findings demonstrate that <i>ARG1</i> rs2781666 SNP is significantly associated with an increased susceptibility to DR in T2DM patients.Monika BuraczynskaIzabela ZakrockaMDPI AGarticlearginase 1diabetic retinopathysingle nucleotide polymorphismrs2781666genotypingMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5407, p 5407 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arginase 1 diabetic retinopathy single nucleotide polymorphism rs2781666 genotyping Medicine R
spellingShingle	arginase 1 diabetic retinopathy single nucleotide polymorphism rs2781666 genotyping Medicine R Monika Buraczynska Izabela Zakrocka Arginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
description	Studies have demonstrated that polymorphic variants of arginase 1 gene (<i>ARG1</i>) are involved in human diseases, such as coronary heart disease, hypertension, and diabetes. Our study aimed to investigate the association between <i>ARG1</i> rs2781666 single nucleotide polymorphism (SNP) and diabetic retinopathy (DR) in type 2 diabetes (T2DM) patients. Polymorphism was genotyped in 740 T2DM patients and 400 healthy individuals. A significant difference in the genotype distribution was observed between the patients and the controls. The T allele and TT genotype were associated with an increased risk of T2DM (OR 1.4, 95% CI 1.14–1.72, <i>p</i> = 0.001 and OR 2.16, 95% CI 1.23–3.80, <i>p</i> = 0.007, respectively). When the T2DM subjects were stratified into DR+ and DR− subgroups, the T allele and TT genotype frequencies were significantly higher in the DR+ group compared to the DR− group, demonstrating OR 1.68 (1.33–2.12), <i>p</i> < 0.0001 and OR 2.39 (1.36–4.18), <i>p</i> = 0.002, respectively. Logistic regression analysis was applied to determine the interaction between the <i>ARG1</i> genotypes and other risk factors. Only <i>ARG1</i> rs2781666 SNP was a significant risk predictor of DR (<i>p</i> = 0.003). In conclusion, this is the first report discussing the effect of <i>ARG1</i> polymorphism on the microvascular complications that are associated with diabetes. Our findings demonstrate that <i>ARG1</i> rs2781666 SNP is significantly associated with an increased susceptibility to DR in T2DM patients.
format	article
author	Monika Buraczynska Izabela Zakrocka
author_facet	Monika Buraczynska Izabela Zakrocka
author_sort	Monika Buraczynska
title	Arginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
title_short	Arginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
title_full	Arginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
title_fullStr	Arginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
title_full_unstemmed	Arginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
title_sort	arginase gene polymorphism increases risk of diabetic retinopathy in type 2 diabetes mellitus patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/23a6679ea2ac485587107b8f03fa1771
work_keys_str_mv	AT monikaburaczynska arginasegenepolymorphismincreasesriskofdiabeticretinopathyintype2diabetesmellituspatients AT izabelazakrocka arginasegenepolymorphismincreasesriskofdiabeticretinopathyintype2diabetesmellituspatients
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Arginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients

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