National cohort and meteorological data based nested case–control study on the association between air pollution exposure and thyroid cancer

Abstract The objective of this study was to evaluate the influence of exposure to meteorological conditions, including air pollution, on thyroid cancer. A nested case–control study was conducted utilizing 4632 patients with thyroid cancer and 18,528 control subjects who were matched at a 1:4 ratio b...

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Autores principales:	Sung Joon Park, Chanyang Min, Dae Myoung Yoo, Hyo Geun Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23a7a93d95444d08bfb5842c06e0f6a8
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spelling	oai:doaj.org-article:23a7a93d95444d08bfb5842c06e0f6a82021-11-08T10:56:01ZNational cohort and meteorological data based nested case–control study on the association between air pollution exposure and thyroid cancer10.1038/s41598-021-00882-72045-2322https://doaj.org/article/23a7a93d95444d08bfb5842c06e0f6a82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00882-7https://doaj.org/toc/2045-2322Abstract The objective of this study was to evaluate the influence of exposure to meteorological conditions, including air pollution, on thyroid cancer. A nested case–control study was conducted utilizing 4632 patients with thyroid cancer and 18,528 control subjects who were matched at a 1:4 ratio by age group, sex, income, and region of residence. Korean National Health Insurance Service-Health Screening Cohort data from 2002 to 2015 were used. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for thyroid cancer correlated with meteorological and air pollution exposure over a moving average of 3 years before the index dates. For all participants, the adjusted ORs associated with relative humidity (1.01, 95% CI 1.00–1.03, P value = 0.023), ambient atmospheric pressure (1.02, 95% CI 1.01–1.03, P value < 0.001), and sunshine duration (1.17, 95% CI 1.04–1.31, P value = 0.007) indicated correlations with the occurrence of thyroid cancer; however, these results were inconsistent in the subgroup analyses. Overall, exposure to nitrogen dioxide (NO2) (1.33, 95% CI 1.24–1.43, P value < 0.001) and particulate matter (PM10) (0.64, 95% CI 0.60–0.69, P value < 0.001) were related to thyroid cancer. These relationships persisted in the subgroup analyses. In conclusion, thyroid cancer occurrence was positively associated with NO2 exposure and negatively associated with PM10 exposure.Sung Joon ParkChanyang MinDae Myoung YooHyo Geun ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sung Joon Park Chanyang Min Dae Myoung Yoo Hyo Geun Choi National cohort and meteorological data based nested case–control study on the association between air pollution exposure and thyroid cancer
description	Abstract The objective of this study was to evaluate the influence of exposure to meteorological conditions, including air pollution, on thyroid cancer. A nested case–control study was conducted utilizing 4632 patients with thyroid cancer and 18,528 control subjects who were matched at a 1:4 ratio by age group, sex, income, and region of residence. Korean National Health Insurance Service-Health Screening Cohort data from 2002 to 2015 were used. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for thyroid cancer correlated with meteorological and air pollution exposure over a moving average of 3 years before the index dates. For all participants, the adjusted ORs associated with relative humidity (1.01, 95% CI 1.00–1.03, P value = 0.023), ambient atmospheric pressure (1.02, 95% CI 1.01–1.03, P value < 0.001), and sunshine duration (1.17, 95% CI 1.04–1.31, P value = 0.007) indicated correlations with the occurrence of thyroid cancer; however, these results were inconsistent in the subgroup analyses. Overall, exposure to nitrogen dioxide (NO2) (1.33, 95% CI 1.24–1.43, P value < 0.001) and particulate matter (PM10) (0.64, 95% CI 0.60–0.69, P value < 0.001) were related to thyroid cancer. These relationships persisted in the subgroup analyses. In conclusion, thyroid cancer occurrence was positively associated with NO2 exposure and negatively associated with PM10 exposure.
format	article
author	Sung Joon Park Chanyang Min Dae Myoung Yoo Hyo Geun Choi
author_facet	Sung Joon Park Chanyang Min Dae Myoung Yoo Hyo Geun Choi
author_sort	Sung Joon Park
title	National cohort and meteorological data based nested case–control study on the association between air pollution exposure and thyroid cancer
title_short	National cohort and meteorological data based nested case–control study on the association between air pollution exposure and thyroid cancer
title_full	National cohort and meteorological data based nested case–control study on the association between air pollution exposure and thyroid cancer
title_fullStr	National cohort and meteorological data based nested case–control study on the association between air pollution exposure and thyroid cancer
title_full_unstemmed	National cohort and meteorological data based nested case–control study on the association between air pollution exposure and thyroid cancer
title_sort	national cohort and meteorological data based nested case–control study on the association between air pollution exposure and thyroid cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23a7a93d95444d08bfb5842c06e0f6a8
work_keys_str_mv	AT sungjoonpark nationalcohortandmeteorologicaldatabasednestedcasecontrolstudyontheassociationbetweenairpollutionexposureandthyroidcancer AT chanyangmin nationalcohortandmeteorologicaldatabasednestedcasecontrolstudyontheassociationbetweenairpollutionexposureandthyroidcancer AT daemyoungyoo nationalcohortandmeteorologicaldatabasednestedcasecontrolstudyontheassociationbetweenairpollutionexposureandthyroidcancer AT hyogeunchoi nationalcohortandmeteorologicaldatabasednestedcasecontrolstudyontheassociationbetweenairpollutionexposureandthyroidcancer
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National cohort and meteorological data based nested case–control study on the association between air pollution exposure and thyroid cancer

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