Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer

Abstract Patients undergoing intensity-modulated radiotherapy (IMRT) for head and neck cancer may have increased incidence of dry eye disease and the exact mechanism is unclear. The present study aims to assess tear film and meibomian gland (MG) features in patients who received IMRT for head and ne...

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Autores principales:	Xiangjun Chen, Reza A. Badian, Håvard Hynne, Cecilie Delphin Amdal, Bente Brokstad Herlofson, Øygunn Aass Utheim, Kristine Løken Westgaard, Fredrik Fineide, Janicke Liaaen Jensen, Tor Paaske Utheim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23ae07d87f134bd186079dedc60e7a69
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spelling	oai:doaj.org-article:23ae07d87f134bd186079dedc60e7a692021-11-21T12:17:17ZAlterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer10.1038/s41598-021-01844-92045-2322https://doaj.org/article/23ae07d87f134bd186079dedc60e7a692021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01844-9https://doaj.org/toc/2045-2322Abstract Patients undergoing intensity-modulated radiotherapy (IMRT) for head and neck cancer may have increased incidence of dry eye disease and the exact mechanism is unclear. The present study aims to assess tear film and meibomian gland (MG) features in patients who received IMRT for head and neck cancer not involving the orbital area. Twenty-seven patients (64.7 ± 9.8 years) and 30 age-matched controls (61.4 ± 11.0 years) underwent a comprehensive dry eye work-up. Compared to the control group, the patients had more lid margin abnormalities, and worse meibum quality. The MG loss, calculated as (tarsal area-MG area)/tarsal area, was higher in the patient group in both the upper (53.0 ± 12.0% vs. 35.1 ± 10.3%, p < 0.001) and lower lids (69.5 ± 12.6% vs. 48.5 ± 12.5%, p < 0.001). In the patient group, more MG loss in the lower lids correlated with worse meibum quality (r = 0.445, p = 0.029). In contrast, there was no significant difference in aqueous tear production level, measured with Schirmer test. Patients treated with IMRT for head and neck cancer seemed to have comparable lacrimal gland function to the controls despite more dry eye symptoms. However, the patients had MG functional and morphological changes, which may present a higher risk for developing dry eye disease.Xiangjun ChenReza A. BadianHåvard HynneCecilie Delphin AmdalBente Brokstad HerlofsonØygunn Aass UtheimKristine Løken WestgaardFredrik FineideJanicke Liaaen JensenTor Paaske UtheimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiangjun Chen Reza A. Badian Håvard Hynne Cecilie Delphin Amdal Bente Brokstad Herlofson Øygunn Aass Utheim Kristine Løken Westgaard Fredrik Fineide Janicke Liaaen Jensen Tor Paaske Utheim Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer
description	Abstract Patients undergoing intensity-modulated radiotherapy (IMRT) for head and neck cancer may have increased incidence of dry eye disease and the exact mechanism is unclear. The present study aims to assess tear film and meibomian gland (MG) features in patients who received IMRT for head and neck cancer not involving the orbital area. Twenty-seven patients (64.7 ± 9.8 years) and 30 age-matched controls (61.4 ± 11.0 years) underwent a comprehensive dry eye work-up. Compared to the control group, the patients had more lid margin abnormalities, and worse meibum quality. The MG loss, calculated as (tarsal area-MG area)/tarsal area, was higher in the patient group in both the upper (53.0 ± 12.0% vs. 35.1 ± 10.3%, p < 0.001) and lower lids (69.5 ± 12.6% vs. 48.5 ± 12.5%, p < 0.001). In the patient group, more MG loss in the lower lids correlated with worse meibum quality (r = 0.445, p = 0.029). In contrast, there was no significant difference in aqueous tear production level, measured with Schirmer test. Patients treated with IMRT for head and neck cancer seemed to have comparable lacrimal gland function to the controls despite more dry eye symptoms. However, the patients had MG functional and morphological changes, which may present a higher risk for developing dry eye disease.
format	article
author	Xiangjun Chen Reza A. Badian Håvard Hynne Cecilie Delphin Amdal Bente Brokstad Herlofson Øygunn Aass Utheim Kristine Løken Westgaard Fredrik Fineide Janicke Liaaen Jensen Tor Paaske Utheim
author_facet	Xiangjun Chen Reza A. Badian Håvard Hynne Cecilie Delphin Amdal Bente Brokstad Herlofson Øygunn Aass Utheim Kristine Løken Westgaard Fredrik Fineide Janicke Liaaen Jensen Tor Paaske Utheim
author_sort	Xiangjun Chen
title	Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer
title_short	Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer
title_full	Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer
title_fullStr	Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer
title_full_unstemmed	Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer
title_sort	alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23ae07d87f134bd186079dedc60e7a69
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Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer

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