Microfluidic Simulation and Optimization of Blood Coagulation Factors and Anticoagulants in Polymethyl Methacrylate Microchannels

Blood coagulation is a critical and complex reaction that involves various chemical substances, such as prothrombin, fibrinogen, and fibrin. The process can be divided into three main steps, namely the formation of the prothrombin activator, conversion of prothrombin to thrombin, and conversion of f...

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Autores principales:	Philip Nathaniel Immanuel, Yi-Hsiung Chiu, Song-Jeng Huang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microchannels simulation anticoagulants chemical reaction two phase flow genetic algorithm Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/23ae91b35c284ebaaa3fc56c6948c70d
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spelling	oai:doaj.org-article:23ae91b35c284ebaaa3fc56c6948c70d2021-11-25T17:16:47ZMicrofluidic Simulation and Optimization of Blood Coagulation Factors and Anticoagulants in Polymethyl Methacrylate Microchannels10.3390/coatings111113942079-6412https://doaj.org/article/23ae91b35c284ebaaa3fc56c6948c70d2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6412/11/11/1394https://doaj.org/toc/2079-6412Blood coagulation is a critical and complex reaction that involves various chemical substances, such as prothrombin, fibrinogen, and fibrin. The process can be divided into three main steps, namely the formation of the prothrombin activator, conversion of prothrombin to thrombin, and conversion of fibrinogen to fibrin. In this study, an ANSYS simulation is carried out to determine the prothrombin time (PT) of blood, the chemical changes that occur during coagulation and the anticoagulation factor. The addition of deionized water to the microchannels before the addition of blood and reagents results in a two-phase flow. The evaluation of this two-phase flow is necessary, and dynamic simulations are required to determine the PT. The chemical rate constant and order of the chemical reaction are derived from the actual prothrombin time. Moreover, the genetic algorithms in PYTHON and ANSYS are used to estimate chemical reaction parameters for a 20 s PT. The blood and anticoagulant exhibit increased dynamic behavior in the microchannel. In addition, particles are added to the microchannel and the dynamic mesh method is used to simulate the flow behaviors of the red and white blood cells in the microchannel. The PTs for different volumes of blood are also reported.Philip Nathaniel ImmanuelYi-Hsiung ChiuSong-Jeng HuangMDPI AGarticlemicrochannelssimulationanticoagulantschemical reactiontwo phase flowgenetic algorithmEngineering (General). Civil engineering (General)TA1-2040ENCoatings, Vol 11, Iss 1394, p 1394 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microchannels simulation anticoagulants chemical reaction two phase flow genetic algorithm Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	microchannels simulation anticoagulants chemical reaction two phase flow genetic algorithm Engineering (General). Civil engineering (General) TA1-2040 Philip Nathaniel Immanuel Yi-Hsiung Chiu Song-Jeng Huang Microfluidic Simulation and Optimization of Blood Coagulation Factors and Anticoagulants in Polymethyl Methacrylate Microchannels
description	Blood coagulation is a critical and complex reaction that involves various chemical substances, such as prothrombin, fibrinogen, and fibrin. The process can be divided into three main steps, namely the formation of the prothrombin activator, conversion of prothrombin to thrombin, and conversion of fibrinogen to fibrin. In this study, an ANSYS simulation is carried out to determine the prothrombin time (PT) of blood, the chemical changes that occur during coagulation and the anticoagulation factor. The addition of deionized water to the microchannels before the addition of blood and reagents results in a two-phase flow. The evaluation of this two-phase flow is necessary, and dynamic simulations are required to determine the PT. The chemical rate constant and order of the chemical reaction are derived from the actual prothrombin time. Moreover, the genetic algorithms in PYTHON and ANSYS are used to estimate chemical reaction parameters for a 20 s PT. The blood and anticoagulant exhibit increased dynamic behavior in the microchannel. In addition, particles are added to the microchannel and the dynamic mesh method is used to simulate the flow behaviors of the red and white blood cells in the microchannel. The PTs for different volumes of blood are also reported.
format	article
author	Philip Nathaniel Immanuel Yi-Hsiung Chiu Song-Jeng Huang
author_facet	Philip Nathaniel Immanuel Yi-Hsiung Chiu Song-Jeng Huang
author_sort	Philip Nathaniel Immanuel
title	Microfluidic Simulation and Optimization of Blood Coagulation Factors and Anticoagulants in Polymethyl Methacrylate Microchannels
title_short	Microfluidic Simulation and Optimization of Blood Coagulation Factors and Anticoagulants in Polymethyl Methacrylate Microchannels
title_full	Microfluidic Simulation and Optimization of Blood Coagulation Factors and Anticoagulants in Polymethyl Methacrylate Microchannels
title_fullStr	Microfluidic Simulation and Optimization of Blood Coagulation Factors and Anticoagulants in Polymethyl Methacrylate Microchannels
title_full_unstemmed	Microfluidic Simulation and Optimization of Blood Coagulation Factors and Anticoagulants in Polymethyl Methacrylate Microchannels
title_sort	microfluidic simulation and optimization of blood coagulation factors and anticoagulants in polymethyl methacrylate microchannels
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/23ae91b35c284ebaaa3fc56c6948c70d
work_keys_str_mv	AT philipnathanielimmanuel microfluidicsimulationandoptimizationofbloodcoagulationfactorsandanticoagulantsinpolymethylmethacrylatemicrochannels AT yihsiungchiu microfluidicsimulationandoptimizationofbloodcoagulationfactorsandanticoagulantsinpolymethylmethacrylatemicrochannels AT songjenghuang microfluidicsimulationandoptimizationofbloodcoagulationfactorsandanticoagulantsinpolymethylmethacrylatemicrochannels
_version_	1718412517741428736

Microfluidic Simulation and Optimization of Blood Coagulation Factors and Anticoagulants in Polymethyl Methacrylate Microchannels

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