FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon

FHFs are known to regulate voltage-gated sodium channels (NaVs). Here, the authors compare the role of FHFs in cerebellar granule cell propagation, and find NaVs in the distal axon function independently of FHFs, allowing for faster inactivation rates and reducing energy demands during repetitive sp...

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Autores principales:	Katarzyna Dover, Christopher Marra, Sergio Solinas, Marko Popovic, Sathyaa Subramaniyam, Dejan Zecevic, Egidio D’Angelo, Mitchell Goldfarb
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23b209ca322947afa3adc05e33877f8c
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spelling	oai:doaj.org-article:23b209ca322947afa3adc05e33877f8c2021-12-02T16:57:39ZFHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon10.1038/ncomms128952041-1723https://doaj.org/article/23b209ca322947afa3adc05e33877f8c2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12895https://doaj.org/toc/2041-1723FHFs are known to regulate voltage-gated sodium channels (NaVs). Here, the authors compare the role of FHFs in cerebellar granule cell propagation, and find NaVs in the distal axon function independently of FHFs, allowing for faster inactivation rates and reducing energy demands during repetitive spiking.Katarzyna DoverChristopher MarraSergio SolinasMarko PopovicSathyaa SubramaniyamDejan ZecevicEgidio D’AngeloMitchell GoldfarbNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katarzyna Dover Christopher Marra Sergio Solinas Marko Popovic Sathyaa Subramaniyam Dejan Zecevic Egidio D’Angelo Mitchell Goldfarb FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
description	FHFs are known to regulate voltage-gated sodium channels (NaVs). Here, the authors compare the role of FHFs in cerebellar granule cell propagation, and find NaVs in the distal axon function independently of FHFs, allowing for faster inactivation rates and reducing energy demands during repetitive spiking.
format	article
author	Katarzyna Dover Christopher Marra Sergio Solinas Marko Popovic Sathyaa Subramaniyam Dejan Zecevic Egidio D’Angelo Mitchell Goldfarb
author_facet	Katarzyna Dover Christopher Marra Sergio Solinas Marko Popovic Sathyaa Subramaniyam Dejan Zecevic Egidio D’Angelo Mitchell Goldfarb
author_sort	Katarzyna Dover
title	FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
title_short	FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
title_full	FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
title_fullStr	FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
title_full_unstemmed	FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
title_sort	fhf-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/23b209ca322947afa3adc05e33877f8c
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FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon

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