Vimentin intermediate filaments stabilize dynamic microtubules by direct interactions

The tasks of the cytoskeleton depend on the fine-tuned interplay between the three filamentous components: actin filaments, microtubules, and intermediate filaments. Here, the authors show in a reconstituted in vitro system that vimentin intermediate filaments stabilize microtubules against depolyme...

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Auteurs principaux: Laura Schaedel, Charlotta Lorenz, Anna V. Schepers, Stefan Klumpp, Sarah Köster
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/23b2e8f87d2c4f0b81118609b696d3b4
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Résumé:The tasks of the cytoskeleton depend on the fine-tuned interplay between the three filamentous components: actin filaments, microtubules, and intermediate filaments. Here, the authors show in a reconstituted in vitro system that vimentin intermediate filaments stabilize microtubules against depolymerization and support microtubule rescue by direct interactions.