Transmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia.

<h4>Background</h4>Transmission of Mycobacterium tuberculosis (M. tuberculosis) complex could be possible between farmers and their cattle in Ethiopia.<h4>Methodology/principal findings</h4>A study was conducted in mixed type multi-purposes cattle raising region of Ethiopia o...

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Autores principales:	Gobena Ameni, Konjit Tadesse, Elena Hailu, Yohannes Deresse, Girmay Medhin, Abraham Aseffa, Glyn Hewinson, Martin Vordermeier, Stefan Berg
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23b4128fb656426587f6c45a57158937
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spelling	oai:doaj.org-article:23b4128fb656426587f6c45a571589372021-11-18T08:51:38ZTransmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia.1932-620310.1371/journal.pone.0076891https://doaj.org/article/23b4128fb656426587f6c45a571589372013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24130804/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Transmission of Mycobacterium tuberculosis (M. tuberculosis) complex could be possible between farmers and their cattle in Ethiopia.<h4>Methodology/principal findings</h4>A study was conducted in mixed type multi-purposes cattle raising region of Ethiopia on 287 households (146 households with case of pulmonary tuberculosis (TB) and 141 free of TB) and 287 herds consisting of 2,033 cattle belonging to these households to evaluate transmission of TB between cattle and farmers. Interview, bacteriological examinations and molecular typing were used for human subjects while comparative intradermal tuberculin (CIDT) test, post mortem and bacteriological examinations, and molecular typing were used for animal studies. Herd prevalence of CIDT reactors was 9.4% and was higher (p<0.01) in herds owned by households with TB than in herds owned by TB free households. Animal prevalence was 1.8% and also higher (p<0.01) in cattle owned by households with TB case than in those owned by TB free households. All mycobacteria (141) isolated from farmers were M. tuberculosis, while only five of the 16 isolates from cattle were members of the M. tuberculosis complex (MTC) while the remaining 11 were members of non-tuberculosis mycobacteria (NTM). Further speciation of the five MTC isolates showed that three of the isolates were M. bovis (strain SB1176), while the remaining two were M. tuberculosis strains (SIT149 and SIT53). Pathology scoring method described by "Vordermeier et al. (2002)" was applied and the average severity of pathology in two cattle infected with M. bovis, in 11 infected with NTM and two infected with M. tuberculosis were 5.5, 2.1 and 0.5, respectively.<h4>Conclusions/significance</h4>The results showed that transmission of TB from farmers to cattle by the airborne route sensitizes the cows but rarely leads to TB. Similarly, low transmission of M. bovis between farmers and their cattle was found, suggesting requirement of ingestion of contaminated milk from cows with tuberculous mastitis.Gobena AmeniKonjit TadesseElena HailuYohannes DeresseGirmay MedhinAbraham AseffaGlyn HewinsonMartin VordermeierStefan BergPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e76891 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gobena Ameni Konjit Tadesse Elena Hailu Yohannes Deresse Girmay Medhin Abraham Aseffa Glyn Hewinson Martin Vordermeier Stefan Berg Transmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia.
description	<h4>Background</h4>Transmission of Mycobacterium tuberculosis (M. tuberculosis) complex could be possible between farmers and their cattle in Ethiopia.<h4>Methodology/principal findings</h4>A study was conducted in mixed type multi-purposes cattle raising region of Ethiopia on 287 households (146 households with case of pulmonary tuberculosis (TB) and 141 free of TB) and 287 herds consisting of 2,033 cattle belonging to these households to evaluate transmission of TB between cattle and farmers. Interview, bacteriological examinations and molecular typing were used for human subjects while comparative intradermal tuberculin (CIDT) test, post mortem and bacteriological examinations, and molecular typing were used for animal studies. Herd prevalence of CIDT reactors was 9.4% and was higher (p<0.01) in herds owned by households with TB than in herds owned by TB free households. Animal prevalence was 1.8% and also higher (p<0.01) in cattle owned by households with TB case than in those owned by TB free households. All mycobacteria (141) isolated from farmers were M. tuberculosis, while only five of the 16 isolates from cattle were members of the M. tuberculosis complex (MTC) while the remaining 11 were members of non-tuberculosis mycobacteria (NTM). Further speciation of the five MTC isolates showed that three of the isolates were M. bovis (strain SB1176), while the remaining two were M. tuberculosis strains (SIT149 and SIT53). Pathology scoring method described by "Vordermeier et al. (2002)" was applied and the average severity of pathology in two cattle infected with M. bovis, in 11 infected with NTM and two infected with M. tuberculosis were 5.5, 2.1 and 0.5, respectively.<h4>Conclusions/significance</h4>The results showed that transmission of TB from farmers to cattle by the airborne route sensitizes the cows but rarely leads to TB. Similarly, low transmission of M. bovis between farmers and their cattle was found, suggesting requirement of ingestion of contaminated milk from cows with tuberculous mastitis.
format	article
author	Gobena Ameni Konjit Tadesse Elena Hailu Yohannes Deresse Girmay Medhin Abraham Aseffa Glyn Hewinson Martin Vordermeier Stefan Berg
author_facet	Gobena Ameni Konjit Tadesse Elena Hailu Yohannes Deresse Girmay Medhin Abraham Aseffa Glyn Hewinson Martin Vordermeier Stefan Berg
author_sort	Gobena Ameni
title	Transmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia.
title_short	Transmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia.
title_full	Transmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia.
title_fullStr	Transmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia.
title_full_unstemmed	Transmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia.
title_sort	transmission of mycobacterium tuberculosis between farmers and cattle in central ethiopia.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/23b4128fb656426587f6c45a57158937
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Transmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia.

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