Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease

Increasing evidence suggests that the gut microbiota and the brain are closely connected via the so-called gut–brain axis. Small intestinal bacterial overgrowth (SIBO) is a gut dysbiosis in which the small intestine is abundantly colonized by bacteria that are typically found in the colon. Though no...

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Autores principales:	Adela Dănău, Laura Dumitrescu, Antonia Lefter, Delia Tulbă, Bogdan Ovidiu Popescu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gut dysbiosis gut–brain axis microbiota Parkinson’s disease small intestinal bacterial overgrowth SIBO Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/23b87701ea8e4e95b3d35f52e9e4e842
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spelling	oai:doaj.org-article:23b87701ea8e4e95b3d35f52e9e4e8422021-11-11T17:07:46ZSmall Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease10.3390/ijms2221116631422-00671661-6596https://doaj.org/article/23b87701ea8e4e95b3d35f52e9e4e8422021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11663https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Increasing evidence suggests that the gut microbiota and the brain are closely connected via the so-called gut–brain axis. Small intestinal bacterial overgrowth (SIBO) is a gut dysbiosis in which the small intestine is abundantly colonized by bacteria that are typically found in the colon. Though not a disease, it may result in intestinal symptoms caused by the accumulation of microbial gases in the intestine. Intestinal inflammation, malabsorption and vitamin imbalances may also develop. SIBO can be eradicated by one or several courses of antibiotics but reappears if the predisposing condition persists. Parkinson’s disease (PD) is a common neurodegenerative proteinopathy for which disease modifying interventions are not available. Sporadic forms may start in the gut years before the development of clinical features. Increased gastrointestinal transit time is present in most people with PD early during the course of the disease, predisposing to gut dysbiosis, including SIBO. The role that gut dysbiosis may play in the etiopathogenesis of PD is not fully understood yet. Here, we discuss the possibility that SIBO could contribute to the progression of PD, by promoting or preventing neurodegeneration, thus being a potential target for treatments aiming at slowing down the progression of PD. The direct symptomatic impact of SIBO and its impact on symptomatic medication are also briefly discussed.Adela DănăuLaura DumitrescuAntonia LefterDelia TulbăBogdan Ovidiu PopescuMDPI AGarticlegut dysbiosisgut–brain axismicrobiotaParkinson’s diseasesmall intestinal bacterial overgrowthSIBOBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11663, p 11663 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gut dysbiosis gut–brain axis microbiota Parkinson’s disease small intestinal bacterial overgrowth SIBO Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	gut dysbiosis gut–brain axis microbiota Parkinson’s disease small intestinal bacterial overgrowth SIBO Biology (General) QH301-705.5 Chemistry QD1-999 Adela Dănău Laura Dumitrescu Antonia Lefter Delia Tulbă Bogdan Ovidiu Popescu Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease
description	Increasing evidence suggests that the gut microbiota and the brain are closely connected via the so-called gut–brain axis. Small intestinal bacterial overgrowth (SIBO) is a gut dysbiosis in which the small intestine is abundantly colonized by bacteria that are typically found in the colon. Though not a disease, it may result in intestinal symptoms caused by the accumulation of microbial gases in the intestine. Intestinal inflammation, malabsorption and vitamin imbalances may also develop. SIBO can be eradicated by one or several courses of antibiotics but reappears if the predisposing condition persists. Parkinson’s disease (PD) is a common neurodegenerative proteinopathy for which disease modifying interventions are not available. Sporadic forms may start in the gut years before the development of clinical features. Increased gastrointestinal transit time is present in most people with PD early during the course of the disease, predisposing to gut dysbiosis, including SIBO. The role that gut dysbiosis may play in the etiopathogenesis of PD is not fully understood yet. Here, we discuss the possibility that SIBO could contribute to the progression of PD, by promoting or preventing neurodegeneration, thus being a potential target for treatments aiming at slowing down the progression of PD. The direct symptomatic impact of SIBO and its impact on symptomatic medication are also briefly discussed.
format	article
author	Adela Dănău Laura Dumitrescu Antonia Lefter Delia Tulbă Bogdan Ovidiu Popescu
author_facet	Adela Dănău Laura Dumitrescu Antonia Lefter Delia Tulbă Bogdan Ovidiu Popescu
author_sort	Adela Dănău
title	Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease
title_short	Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease
title_full	Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease
title_fullStr	Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease
title_full_unstemmed	Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease
title_sort	small intestinal bacterial overgrowth as potential therapeutic target in parkinson’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/23b87701ea8e4e95b3d35f52e9e4e842
work_keys_str_mv	AT adeladanau smallintestinalbacterialovergrowthaspotentialtherapeutictargetinparkinsonsdisease AT lauradumitrescu smallintestinalbacterialovergrowthaspotentialtherapeutictargetinparkinsonsdisease AT antonialefter smallintestinalbacterialovergrowthaspotentialtherapeutictargetinparkinsonsdisease AT deliatulba smallintestinalbacterialovergrowthaspotentialtherapeutictargetinparkinsonsdisease AT bogdanovidiupopescu smallintestinalbacterialovergrowthaspotentialtherapeutictargetinparkinsonsdisease
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Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease

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