Ondansetron Compared with Doxylamine and Pyridoxine for Treatment of Nausea and Vomiting in Pregnancy

Background: Nausea and vomiting affects up to 80% of the pregnant women population and are the third leading causes of maternal hospitalization during pregnancy. Many pregnant females, and even some healthcare professionals, dread using antiemetic drugs due to a false beliefof their teratogenicrisk....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohamed Yahia, Khattab Khattab, Alaa Hamed
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	nnausea vomiting doxylamine ondansetron pregnancy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/23bbc3e797ca451f842cc5dcff7fd509
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:23bbc3e797ca451f842cc5dcff7fd509
record_format	dspace
spelling	oai:doaj.org-article:23bbc3e797ca451f842cc5dcff7fd5092021-12-02T13:52:45ZOndansetron Compared with Doxylamine and Pyridoxine for Treatment of Nausea and Vomiting in Pregnancy2636-41742682-378010.21608/ijma.2020.26371.1111https://doaj.org/article/23bbc3e797ca451f842cc5dcff7fd5092020-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_98192_7cd2f2a5e8bbc1bcb14e9b27778a0c0d.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Nausea and vomiting affects up to 80% of the pregnant women population and are the third leading causes of maternal hospitalization during pregnancy. Many pregnant females, and even some healthcare professionals, dread using antiemetic drugs due to a false beliefof their teratogenicrisk. Aim of the work:This study aimed to evaluate ondansetron to a combination of doxylamine and pyridoxine in controlling pregnancy-related nausea and vomiting. Patients and Methods:This randomized controlled trial included 156 pregnant women, at 16 weeks of gestation, with mild-to-moderate nausea and vomiting. Meanwhile, women with severe symptoms indicating admission, those already on anti-emetics, and those who wouldn’t be able to show up for follow-up visits were excluded. Seventy-eight patients received intravenous injection of ondansetron [Zofran] at a dose of 8 mg once daily for 5 days, whereas the other 78 patients received oral pyridoxine at a dose of 25 mg plus doxylamine at a dose of 12.5 mg [Diclegis] twice daily for 5 days. Each patient was subjected to full history taking, complete clinical examination and investigations. Results: Women on Ondansetron reported better alleviation of nausea compared to those receiving pyridoxine and doxylamine [96.2% vs. 52.6%, P<0.001, respectively]. The most frequently reported side effects were headache, dry mouth, gastrointestinal [GI] disturbances, and abdominal pain, and the differences in their occurrence between the two groups were statistically insignificant. Conclusion: Ondansetron was found superior to the combination of pyridoxine and doxylamine in improving pregnancy-related nausea and vomiting occurring without a significant increase in side effects.Mohamed YahiaKhattab KhattabAlaa HamedAl-Azhar University, Faculty of Medicine (Damietta)articlennauseavomitingdoxylamineondansetronpregnancyMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 3, Pp 611-618 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nnausea vomiting doxylamine ondansetron pregnancy Medicine (General) R5-920
spellingShingle	nnausea vomiting doxylamine ondansetron pregnancy Medicine (General) R5-920 Mohamed Yahia Khattab Khattab Alaa Hamed Ondansetron Compared with Doxylamine and Pyridoxine for Treatment of Nausea and Vomiting in Pregnancy
description	Background: Nausea and vomiting affects up to 80% of the pregnant women population and are the third leading causes of maternal hospitalization during pregnancy. Many pregnant females, and even some healthcare professionals, dread using antiemetic drugs due to a false beliefof their teratogenicrisk. Aim of the work:This study aimed to evaluate ondansetron to a combination of doxylamine and pyridoxine in controlling pregnancy-related nausea and vomiting. Patients and Methods:This randomized controlled trial included 156 pregnant women, at 16 weeks of gestation, with mild-to-moderate nausea and vomiting. Meanwhile, women with severe symptoms indicating admission, those already on anti-emetics, and those who wouldn’t be able to show up for follow-up visits were excluded. Seventy-eight patients received intravenous injection of ondansetron [Zofran] at a dose of 8 mg once daily for 5 days, whereas the other 78 patients received oral pyridoxine at a dose of 25 mg plus doxylamine at a dose of 12.5 mg [Diclegis] twice daily for 5 days. Each patient was subjected to full history taking, complete clinical examination and investigations. Results: Women on Ondansetron reported better alleviation of nausea compared to those receiving pyridoxine and doxylamine [96.2% vs. 52.6%, P<0.001, respectively]. The most frequently reported side effects were headache, dry mouth, gastrointestinal [GI] disturbances, and abdominal pain, and the differences in their occurrence between the two groups were statistically insignificant. Conclusion: Ondansetron was found superior to the combination of pyridoxine and doxylamine in improving pregnancy-related nausea and vomiting occurring without a significant increase in side effects.
format	article
author	Mohamed Yahia Khattab Khattab Alaa Hamed
author_facet	Mohamed Yahia Khattab Khattab Alaa Hamed
author_sort	Mohamed Yahia
title	Ondansetron Compared with Doxylamine and Pyridoxine for Treatment of Nausea and Vomiting in Pregnancy
title_short	Ondansetron Compared with Doxylamine and Pyridoxine for Treatment of Nausea and Vomiting in Pregnancy
title_full	Ondansetron Compared with Doxylamine and Pyridoxine for Treatment of Nausea and Vomiting in Pregnancy
title_fullStr	Ondansetron Compared with Doxylamine and Pyridoxine for Treatment of Nausea and Vomiting in Pregnancy
title_full_unstemmed	Ondansetron Compared with Doxylamine and Pyridoxine for Treatment of Nausea and Vomiting in Pregnancy
title_sort	ondansetron compared with doxylamine and pyridoxine for treatment of nausea and vomiting in pregnancy
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/23bbc3e797ca451f842cc5dcff7fd509
work_keys_str_mv	AT mohamedyahia ondansetroncomparedwithdoxylamineandpyridoxinefortreatmentofnauseaandvomitinginpregnancy AT khattabkhattab ondansetroncomparedwithdoxylamineandpyridoxinefortreatmentofnauseaandvomitinginpregnancy AT alaahamed ondansetroncomparedwithdoxylamineandpyridoxinefortreatmentofnauseaandvomitinginpregnancy
_version_	1718392367555280896

Ondansetron Compared with Doxylamine and Pyridoxine for Treatment of Nausea and Vomiting in Pregnancy

Ejemplares similares