White matter alterations in glaucoma and monocular blindness differ outside the visual system

Abstract The degree to which glaucoma has effects in the brain beyond the eye and the visual pathways is unclear. To clarify this, we investigated white matter microstructure (WMM) in 37 tracts of patients with glaucoma, monocular blindness, and controls. We used brainlife.io for reproducibility. Wh...

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Autores principales:	Sandra Hanekamp, Branislava Ćurčić-Blake, Bradley Caron, Brent McPherson, Anneleen Timmer, Doety Prins, Christine C. Boucard, Masaki Yoshida, Masahiro Ida, David Hunt, Nomdo M. Jansonius, Franco Pestilli, Frans W. Cornelissen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23bee6d2b7ef444e8702f459a51b871f
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spelling	oai:doaj.org-article:23bee6d2b7ef444e8702f459a51b871f2021-12-02T11:45:01ZWhite matter alterations in glaucoma and monocular blindness differ outside the visual system10.1038/s41598-021-85602-x2045-2322https://doaj.org/article/23bee6d2b7ef444e8702f459a51b871f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85602-xhttps://doaj.org/toc/2045-2322Abstract The degree to which glaucoma has effects in the brain beyond the eye and the visual pathways is unclear. To clarify this, we investigated white matter microstructure (WMM) in 37 tracts of patients with glaucoma, monocular blindness, and controls. We used brainlife.io for reproducibility. White matter tracts were subdivided into seven categories ranging from those primarily involved in vision (the visual white matter) to those primarily involved in cognition and motor control. In the vision tracts, WMM was decreased as measured by fractional anisotropy in both glaucoma and monocular blind subjects compared to controls, suggesting neurodegeneration due to reduced sensory inputs. A test–retest approach was used to validate these results. The pattern of results was different in monocular blind subjects, where WMM properties increased outside the visual white matter as compared to controls. This pattern of results suggests that whereas in the monocular blind loss of visual input might promote white matter reorganization outside of the early visual system, such reorganization might be reduced or absent in glaucoma. The results provide indirect evidence that in glaucoma unknown factors might limit the reorganization as seen in other patient groups following visual loss.Sandra HanekampBranislava Ćurčić-BlakeBradley CaronBrent McPhersonAnneleen TimmerDoety PrinsChristine C. BoucardMasaki YoshidaMasahiro IdaDavid HuntNomdo M. JansoniusFranco PestilliFrans W. CornelissenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandra Hanekamp Branislava Ćurčić-Blake Bradley Caron Brent McPherson Anneleen Timmer Doety Prins Christine C. Boucard Masaki Yoshida Masahiro Ida David Hunt Nomdo M. Jansonius Franco Pestilli Frans W. Cornelissen White matter alterations in glaucoma and monocular blindness differ outside the visual system
description	Abstract The degree to which glaucoma has effects in the brain beyond the eye and the visual pathways is unclear. To clarify this, we investigated white matter microstructure (WMM) in 37 tracts of patients with glaucoma, monocular blindness, and controls. We used brainlife.io for reproducibility. White matter tracts were subdivided into seven categories ranging from those primarily involved in vision (the visual white matter) to those primarily involved in cognition and motor control. In the vision tracts, WMM was decreased as measured by fractional anisotropy in both glaucoma and monocular blind subjects compared to controls, suggesting neurodegeneration due to reduced sensory inputs. A test–retest approach was used to validate these results. The pattern of results was different in monocular blind subjects, where WMM properties increased outside the visual white matter as compared to controls. This pattern of results suggests that whereas in the monocular blind loss of visual input might promote white matter reorganization outside of the early visual system, such reorganization might be reduced or absent in glaucoma. The results provide indirect evidence that in glaucoma unknown factors might limit the reorganization as seen in other patient groups following visual loss.
format	article
author	Sandra Hanekamp Branislava Ćurčić-Blake Bradley Caron Brent McPherson Anneleen Timmer Doety Prins Christine C. Boucard Masaki Yoshida Masahiro Ida David Hunt Nomdo M. Jansonius Franco Pestilli Frans W. Cornelissen
author_facet	Sandra Hanekamp Branislava Ćurčić-Blake Bradley Caron Brent McPherson Anneleen Timmer Doety Prins Christine C. Boucard Masaki Yoshida Masahiro Ida David Hunt Nomdo M. Jansonius Franco Pestilli Frans W. Cornelissen
author_sort	Sandra Hanekamp
title	White matter alterations in glaucoma and monocular blindness differ outside the visual system
title_short	White matter alterations in glaucoma and monocular blindness differ outside the visual system
title_full	White matter alterations in glaucoma and monocular blindness differ outside the visual system
title_fullStr	White matter alterations in glaucoma and monocular blindness differ outside the visual system
title_full_unstemmed	White matter alterations in glaucoma and monocular blindness differ outside the visual system
title_sort	white matter alterations in glaucoma and monocular blindness differ outside the visual system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23bee6d2b7ef444e8702f459a51b871f
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White matter alterations in glaucoma and monocular blindness differ outside the visual system

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