Determination of Fosetyl-Aluminum in Wheat Flour with Extract-Dilute-Shoot Procedure and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry

Fosetyl-aluminum is a widely used ionic fungicide. This pesticide is not amenable to the common multi-residue sample preparation methods. Herein, this paper describes a novel method for the simple and sensitive determination of fosetyl-aluminum residue in wheat flour. The sample preparation method i...

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Autores principales:	Xianjiang Li, Sheng Wang, Zhen Guo, Xiuqin Li, Qinghe Zhang, Hongmei Li
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	extract-dilute-shoot fosetyl-aluminum hydrophilic interaction liquid chromatography wheat flour Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/23c2418d816a44b994d203e44c326c39
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spelling	oai:doaj.org-article:23c2418d816a44b994d203e44c326c392021-11-25T18:59:17ZDetermination of Fosetyl-Aluminum in Wheat Flour with Extract-Dilute-Shoot Procedure and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry10.3390/separations81101972297-8739https://doaj.org/article/23c2418d816a44b994d203e44c326c392021-10-01T00:00:00Zhttps://www.mdpi.com/2297-8739/8/11/197https://doaj.org/toc/2297-8739Fosetyl-aluminum is a widely used ionic fungicide. This pesticide is not amenable to the common multi-residue sample preparation methods. Herein, this paper describes a novel method for the simple and sensitive determination of fosetyl-aluminum residue in wheat flour. The sample preparation method involved extraction with water under ultrasonication and subsequent dilution with six-fold acetonitrile. The fosetyl-aluminum concentration was determined by hydrophilic interaction liquid chromatography tandem mass spectrometry. The limit of detection and quantification were only 5 and 10 ng/g, respectively, which meet the requirement of the current European legislation. Matrix-matched linearity (r<sup>2</sup> = 0.9999) was established in the range of 10–2000 ng/g. Satisfactory recoveries were achieved in the range of 95.6% to 105.2% for three levels of spiked samples (10, 50, and 100 ng/g). Finally, the method was applied to analyzing 75 wheat flour samples produced in four provinces in China. Two samples were positive with concentrations over the limit of detection. This is the first method focusing on fosetyl-aluminum determination in wheat flour with an extract-dilute-shoot strategy and is very promising for the routine quality control of fosetyl-aluminum in similar cereal matrices.Xianjiang LiSheng WangZhen GuoXiuqin LiQinghe ZhangHongmei LiMDPI AGarticleextract-dilute-shootfosetyl-aluminumhydrophilic interaction liquid chromatographywheat flourPhysicsQC1-999ChemistryQD1-999ENSeparations, Vol 8, Iss 197, p 197 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extract-dilute-shoot fosetyl-aluminum hydrophilic interaction liquid chromatography wheat flour Physics QC1-999 Chemistry QD1-999
spellingShingle	extract-dilute-shoot fosetyl-aluminum hydrophilic interaction liquid chromatography wheat flour Physics QC1-999 Chemistry QD1-999 Xianjiang Li Sheng Wang Zhen Guo Xiuqin Li Qinghe Zhang Hongmei Li Determination of Fosetyl-Aluminum in Wheat Flour with Extract-Dilute-Shoot Procedure and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry
description	Fosetyl-aluminum is a widely used ionic fungicide. This pesticide is not amenable to the common multi-residue sample preparation methods. Herein, this paper describes a novel method for the simple and sensitive determination of fosetyl-aluminum residue in wheat flour. The sample preparation method involved extraction with water under ultrasonication and subsequent dilution with six-fold acetonitrile. The fosetyl-aluminum concentration was determined by hydrophilic interaction liquid chromatography tandem mass spectrometry. The limit of detection and quantification were only 5 and 10 ng/g, respectively, which meet the requirement of the current European legislation. Matrix-matched linearity (r<sup>2</sup> = 0.9999) was established in the range of 10–2000 ng/g. Satisfactory recoveries were achieved in the range of 95.6% to 105.2% for three levels of spiked samples (10, 50, and 100 ng/g). Finally, the method was applied to analyzing 75 wheat flour samples produced in four provinces in China. Two samples were positive with concentrations over the limit of detection. This is the first method focusing on fosetyl-aluminum determination in wheat flour with an extract-dilute-shoot strategy and is very promising for the routine quality control of fosetyl-aluminum in similar cereal matrices.
format	article
author	Xianjiang Li Sheng Wang Zhen Guo Xiuqin Li Qinghe Zhang Hongmei Li
author_facet	Xianjiang Li Sheng Wang Zhen Guo Xiuqin Li Qinghe Zhang Hongmei Li
author_sort	Xianjiang Li
title	Determination of Fosetyl-Aluminum in Wheat Flour with Extract-Dilute-Shoot Procedure and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry
title_short	Determination of Fosetyl-Aluminum in Wheat Flour with Extract-Dilute-Shoot Procedure and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry
title_full	Determination of Fosetyl-Aluminum in Wheat Flour with Extract-Dilute-Shoot Procedure and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry
title_fullStr	Determination of Fosetyl-Aluminum in Wheat Flour with Extract-Dilute-Shoot Procedure and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry
title_full_unstemmed	Determination of Fosetyl-Aluminum in Wheat Flour with Extract-Dilute-Shoot Procedure and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry
title_sort	determination of fosetyl-aluminum in wheat flour with extract-dilute-shoot procedure and hydrophilic interaction liquid chromatography tandem mass spectrometry
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/23c2418d816a44b994d203e44c326c39
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Determination of Fosetyl-Aluminum in Wheat Flour with Extract-Dilute-Shoot Procedure and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry

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