Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice

Poly(A)-binding protein (PABP) is an RNA binding protein with translation function. Here, Barragán-Iglesias and colleagues devise an RNA mimic that inhibits PABP activity, and show that inhibitors can reduce animal’s pain response in vivo when injected locally.

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Detalles Bibliográficos
Autores principales:	Paulino Barragán-Iglesias, Tzu-Fang Lou, Vandita D. Bhat, Salim Megat, Michael D. Burton, Theodore J. Price, Zachary T. Campbell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23c2643f25c241e3847cf577a3d95504
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spelling	oai:doaj.org-article:23c2643f25c241e3847cf577a3d955042021-12-02T17:31:42ZInhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice10.1038/s41467-017-02449-52041-1723https://doaj.org/article/23c2643f25c241e3847cf577a3d955042018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02449-5https://doaj.org/toc/2041-1723Poly(A)-binding protein (PABP) is an RNA binding protein with translation function. Here, Barragán-Iglesias and colleagues devise an RNA mimic that inhibits PABP activity, and show that inhibitors can reduce animal’s pain response in vivo when injected locally.Paulino Barragán-IglesiasTzu-Fang LouVandita D. BhatSalim MegatMichael D. BurtonTheodore J. PriceZachary T. CampbellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paulino Barragán-Iglesias Tzu-Fang Lou Vandita D. Bhat Salim Megat Michael D. Burton Theodore J. Price Zachary T. Campbell Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice
description	Poly(A)-binding protein (PABP) is an RNA binding protein with translation function. Here, Barragán-Iglesias and colleagues devise an RNA mimic that inhibits PABP activity, and show that inhibitors can reduce animal’s pain response in vivo when injected locally.
format	article
author	Paulino Barragán-Iglesias Tzu-Fang Lou Vandita D. Bhat Salim Megat Michael D. Burton Theodore J. Price Zachary T. Campbell
author_facet	Paulino Barragán-Iglesias Tzu-Fang Lou Vandita D. Bhat Salim Megat Michael D. Burton Theodore J. Price Zachary T. Campbell
author_sort	Paulino Barragán-Iglesias
title	Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice
title_short	Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice
title_full	Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice
title_fullStr	Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice
title_full_unstemmed	Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice
title_sort	inhibition of poly(a)-binding protein with a synthetic rna mimic reduces pain sensitization in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/23c2643f25c241e3847cf577a3d95504
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Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice

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