Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice
Poly(A)-binding protein (PABP) is an RNA binding protein with translation function. Here, Barragán-Iglesias and colleagues devise an RNA mimic that inhibits PABP activity, and show that inhibitors can reduce animal’s pain response in vivo when injected locally.
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Autores principales: | Paulino Barragán-Iglesias, Tzu-Fang Lou, Vandita D. Bhat, Salim Megat, Michael D. Burton, Theodore J. Price, Zachary T. Campbell |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/23c2643f25c241e3847cf577a3d95504 |
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