Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na<sup>+</sup>-Taurine Symporter

Although insulin-induced cardiac hypertrophy is reported, very little information is available on the hypertrophic effect of insulin on ventricular cardiomyocytes and the regulation of sodium and calcium homeostasis. Taurine is a non-essential amino acid synthesized by cardiomyocytes and the brain a...

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Autores principales:	Ashley Jazzar, Danielle Jacques, Ghassan Bkaily
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	taurine insulin cardiomyocytes hypertrophy sodium calcium Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/23c66286d07c43368d28a00cb548fe24
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spelling	oai:doaj.org-article:23c66286d07c43368d28a00cb548fe242021-11-25T18:33:11ZInsulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na<sup>+</sup>-Taurine Symporter10.3390/nu131136862072-6643https://doaj.org/article/23c66286d07c43368d28a00cb548fe242021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3686https://doaj.org/toc/2072-6643Although insulin-induced cardiac hypertrophy is reported, very little information is available on the hypertrophic effect of insulin on ventricular cardiomyocytes and the regulation of sodium and calcium homeostasis. Taurine is a non-essential amino acid synthesized by cardiomyocytes and the brain and is present in low quantities in many foods, particularly seafood. The purpose of this study was to investigate whether chronic exposure to insulin induces hypertrophy of ventricular cardiomyocytes that are associated with changes in Na<sup>+</sup> and Ca<sup>2+</sup> homeostasis and whether taurine pre-treatment prevents these effects. Our results showed that chronic treatment with insulin leads to cardiomyocyte hypertrophy that is associated with an increase in basal intracellular Na<sup>+</sup> and Ca<sup>2+</sup> levels. Furthermore, long-term taurine treatment prevents morphological and ionic remodeling induced by insulin. In addition, blocking the Na<sup>+</sup>-taurine co-transporter prevented the taurine antihypertrophic effect. Finally, the insulin-induced remodeling of cardiomyocytes was associated with a decrease in the ratio of phospho-CREB (pCREB) to total cAMP response element binding protein (CREB); taurine prevented this effect. In conclusion, our results show that insulin induces ventricular cardiomyocyte hypertrophy via downregulation of the pCREB/tCREB level and that chronic taurine treatment prevents this effect.Ashley JazzarDanielle JacquesGhassan BkailyMDPI AGarticletaurineinsulincardiomyocyteshypertrophysodiumcalciumNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3686, p 3686 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	taurine insulin cardiomyocytes hypertrophy sodium calcium Nutrition. Foods and food supply TX341-641
spellingShingle	taurine insulin cardiomyocytes hypertrophy sodium calcium Nutrition. Foods and food supply TX341-641 Ashley Jazzar Danielle Jacques Ghassan Bkaily Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na<sup>+</sup>-Taurine Symporter
description	Although insulin-induced cardiac hypertrophy is reported, very little information is available on the hypertrophic effect of insulin on ventricular cardiomyocytes and the regulation of sodium and calcium homeostasis. Taurine is a non-essential amino acid synthesized by cardiomyocytes and the brain and is present in low quantities in many foods, particularly seafood. The purpose of this study was to investigate whether chronic exposure to insulin induces hypertrophy of ventricular cardiomyocytes that are associated with changes in Na<sup>+</sup> and Ca<sup>2+</sup> homeostasis and whether taurine pre-treatment prevents these effects. Our results showed that chronic treatment with insulin leads to cardiomyocyte hypertrophy that is associated with an increase in basal intracellular Na<sup>+</sup> and Ca<sup>2+</sup> levels. Furthermore, long-term taurine treatment prevents morphological and ionic remodeling induced by insulin. In addition, blocking the Na<sup>+</sup>-taurine co-transporter prevented the taurine antihypertrophic effect. Finally, the insulin-induced remodeling of cardiomyocytes was associated with a decrease in the ratio of phospho-CREB (pCREB) to total cAMP response element binding protein (CREB); taurine prevented this effect. In conclusion, our results show that insulin induces ventricular cardiomyocyte hypertrophy via downregulation of the pCREB/tCREB level and that chronic taurine treatment prevents this effect.
format	article
author	Ashley Jazzar Danielle Jacques Ghassan Bkaily
author_facet	Ashley Jazzar Danielle Jacques Ghassan Bkaily
author_sort	Ashley Jazzar
title	Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na<sup>+</sup>-Taurine Symporter
title_short	Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na<sup>+</sup>-Taurine Symporter
title_full	Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na<sup>+</sup>-Taurine Symporter
title_fullStr	Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na<sup>+</sup>-Taurine Symporter
title_full_unstemmed	Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na<sup>+</sup>-Taurine Symporter
title_sort	insulin-induced cardiomyocytes hypertrophy that is prevented by taurine via β-alanine-sensitive na<sup>+</sup>-taurine symporter
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/23c66286d07c43368d28a00cb548fe24
work_keys_str_mv	AT ashleyjazzar insulininducedcardiomyocyteshypertrophythatispreventedbytaurineviabalaninesensitivenasupsuptaurinesymporter AT daniellejacques insulininducedcardiomyocyteshypertrophythatispreventedbytaurineviabalaninesensitivenasupsuptaurinesymporter AT ghassanbkaily insulininducedcardiomyocyteshypertrophythatispreventedbytaurineviabalaninesensitivenasupsuptaurinesymporter
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Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na<sup>+</sup>-Taurine Symporter

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