Ten-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two Italian cases

Bernardo Dell’Osso,1–3 Lucio Oldani,1 Benedetta Grancini,1 Alessandro Dario,4 A Carlo Altamura1 1Department of Psychiatry, University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 2Department of Psychiatry and Behavioral Sciences,...

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Autores principales:	Dell'Osso B, Oldani L, Grancini B, Dario A, Altamura AC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	vagus nerve stimulation (VNS) treatment resistant depression (TRD) long-term follow up Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/23c9a45793684a5eb305277b2f9b6673
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spelling	oai:doaj.org-article:23c9a45793684a5eb305277b2f9b66732021-12-02T00:21:56ZTen-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two Italian cases1178-2021https://doaj.org/article/23c9a45793684a5eb305277b2f9b66732018-03-01T00:00:00Zhttps://www.dovepress.com/ten-year-outcome-of-vagus-nerve-stimulation-implanted-patients-with-tr-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Bernardo Dell’Osso,1–3 Lucio Oldani,1 Benedetta Grancini,1 Alessandro Dario,4 A Carlo Altamura1 1Department of Psychiatry, University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 2Department of Psychiatry and Behavioral Sciences, Bipolar Disorders Clinic, Stanford Medical School, Stanford University, Stanford, CA, USA; 3CRC “Aldo Ravelli” for Neurotechnology and Experimental Brain Therapeutics, University of Milan, Milan, Italy; 4Department of Neurosurgery, Macchi Foundation Hospital, Varese, Italy Abstract: Over the last 15 years, vagus nerve stimulation (VNS) has been used as an augmentative therapeutic intervention in patients with treatment-resistant depression (TRD), whether with a lifetime diagnosis of major depressive disorder or bipolar disorder. From being a potentially effective treatment in the acute phase of TRD, recently published treatment guidelines seemed to converge on the indication that VNS’s greatest benefit may be seen mostly beyond the short term. However, with the exception of a recent multicenter American report, very few studies have assessed the long-term efficacy of VNS in TRD patients. Herein, we present the cases of two Italian patients with TRD, with 10-year VNS follow-up evaluation. Both patients were found to benefit from augmentative VNS, and the latency of their stimulation response, tolerability, associated pharmacological treatment, number and duration of recurrences, and overall level of functioning are described and discussed. Further reports with larger samples are needed to support the long-term efficacy and tolerability of VNS in TRD patients, particularly beyond 5 years of follow-up. Keywords: vagus nerve stimulation, treatment-resistant depression, long-term follow-up, MDD, bipolar disorderDell'Osso BOldani LGrancini BDario AAltamura ACDove Medical Pressarticlevagus nerve stimulation (VNS)treatment resistant depression (TRD)long-term follow upNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 915-918 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	vagus nerve stimulation (VNS) treatment resistant depression (TRD) long-term follow up Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	vagus nerve stimulation (VNS) treatment resistant depression (TRD) long-term follow up Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Dell'Osso B Oldani L Grancini B Dario A Altamura AC Ten-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two Italian cases
description	Bernardo Dell’Osso,1–3 Lucio Oldani,1 Benedetta Grancini,1 Alessandro Dario,4 A Carlo Altamura1 1Department of Psychiatry, University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 2Department of Psychiatry and Behavioral Sciences, Bipolar Disorders Clinic, Stanford Medical School, Stanford University, Stanford, CA, USA; 3CRC “Aldo Ravelli” for Neurotechnology and Experimental Brain Therapeutics, University of Milan, Milan, Italy; 4Department of Neurosurgery, Macchi Foundation Hospital, Varese, Italy Abstract: Over the last 15 years, vagus nerve stimulation (VNS) has been used as an augmentative therapeutic intervention in patients with treatment-resistant depression (TRD), whether with a lifetime diagnosis of major depressive disorder or bipolar disorder. From being a potentially effective treatment in the acute phase of TRD, recently published treatment guidelines seemed to converge on the indication that VNS’s greatest benefit may be seen mostly beyond the short term. However, with the exception of a recent multicenter American report, very few studies have assessed the long-term efficacy of VNS in TRD patients. Herein, we present the cases of two Italian patients with TRD, with 10-year VNS follow-up evaluation. Both patients were found to benefit from augmentative VNS, and the latency of their stimulation response, tolerability, associated pharmacological treatment, number and duration of recurrences, and overall level of functioning are described and discussed. Further reports with larger samples are needed to support the long-term efficacy and tolerability of VNS in TRD patients, particularly beyond 5 years of follow-up. Keywords: vagus nerve stimulation, treatment-resistant depression, long-term follow-up, MDD, bipolar disorder
format	article
author	Dell'Osso B Oldani L Grancini B Dario A Altamura AC
author_facet	Dell'Osso B Oldani L Grancini B Dario A Altamura AC
author_sort	Dell'Osso B
title	Ten-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two Italian cases
title_short	Ten-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two Italian cases
title_full	Ten-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two Italian cases
title_fullStr	Ten-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two Italian cases
title_full_unstemmed	Ten-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two Italian cases
title_sort	ten-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two italian cases
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/23c9a45793684a5eb305277b2f9b6673
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_version_	1718403788731056128

Ten-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two Italian cases

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