Effects of intracranial atherosclerosis and atrial fibrillation on the prognosis of ischemic stroke with active cancer.

Effects of intracranial atherosclerosis and atrial fibrillation on the prognosis of ischemic stroke with active cancer.

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<h4>Background</h4>In ischemic stroke patients with active cancer, cryptogenic stroke has worse prognosis than stroke by conventional mechanisms. However, the individual effects of intracranial atherosclerosis (ICAS) or atrial fibrillation (AF) on the prognosis of these patients have not...

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Autores principales: Ki-Woong Nam, Hyung-Min Kwon, Yong-Seok Lee
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/23cae7ae55cf4d708e419aaab9464ac2
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spelling oai:doaj.org-article:23cae7ae55cf4d708e419aaab9464ac22021-12-02T20:06:01ZEffects of intracranial atherosclerosis and atrial fibrillation on the prognosis of ischemic stroke with active cancer.1932-620310.1371/journal.pone.0259627https://doaj.org/article/23cae7ae55cf4d708e419aaab9464ac22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259627https://doaj.org/toc/1932-6203<h4>Background</h4>In ischemic stroke patients with active cancer, cryptogenic stroke has worse prognosis than stroke by conventional mechanisms. However, the individual effects of intracranial atherosclerosis (ICAS) or atrial fibrillation (AF) on the prognosis of these patients have not been studied.<h4>Aims</h4>Therefore, we aimed to investigate the effects of ICAS and AF on the prognosis of ischemic stroke patients with active cancer.<h4>Methods</h4>We included ischemic stroke patients with active cancer between 2010 and 2020. Early neurological deterioration (END) was defined as an increase of ≥ 1 in the motor NIHSS score, or ≥ 2 in the total NIHSS score within 72 hours of admission. Unfavorable outcomes were defined as a score of ≥ 3 on the 3-month modified Rankin Scale.<h4>Results</h4>In total, 116 ischemic stroke patients with active cancer were evaluated. In multivariable analysis, ICAS was positively associated with END (adjusted odds ratio [aOR] = 4.56, 95% confidence interval [CI]: 1.52-13.70), and this association showed a quantitative relationship according to the degree of stenosis of ICAS (stenosis group: aOR = 4.24, 95% CI: 1.31-13.72; occlusion group, aOR = 5.74, 95% CI: 1.05-31.30). ICAS was also closely related to unfavorable outcomes (aOR = 6.33, 95% CI: 1.15-34.79). In contrast, AF showed no significant association with END or unfavorable outcomes. Our data showed that patients with ICAS had larger and more severe initial stroke lesions, and poorer prognosis than those without.<h4>Conclusions</h4>ICAS, but not AF, was closely associated with poor prognosis in ischemic stroke patients with active cancer.Ki-Woong NamHyung-Min KwonYong-Seok LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259627 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ki-Woong Nam
Hyung-Min Kwon
Yong-Seok Lee
Effects of intracranial atherosclerosis and atrial fibrillation on the prognosis of ischemic stroke with active cancer.
description <h4>Background</h4>In ischemic stroke patients with active cancer, cryptogenic stroke has worse prognosis than stroke by conventional mechanisms. However, the individual effects of intracranial atherosclerosis (ICAS) or atrial fibrillation (AF) on the prognosis of these patients have not been studied.<h4>Aims</h4>Therefore, we aimed to investigate the effects of ICAS and AF on the prognosis of ischemic stroke patients with active cancer.<h4>Methods</h4>We included ischemic stroke patients with active cancer between 2010 and 2020. Early neurological deterioration (END) was defined as an increase of ≥ 1 in the motor NIHSS score, or ≥ 2 in the total NIHSS score within 72 hours of admission. Unfavorable outcomes were defined as a score of ≥ 3 on the 3-month modified Rankin Scale.<h4>Results</h4>In total, 116 ischemic stroke patients with active cancer were evaluated. In multivariable analysis, ICAS was positively associated with END (adjusted odds ratio [aOR] = 4.56, 95% confidence interval [CI]: 1.52-13.70), and this association showed a quantitative relationship according to the degree of stenosis of ICAS (stenosis group: aOR = 4.24, 95% CI: 1.31-13.72; occlusion group, aOR = 5.74, 95% CI: 1.05-31.30). ICAS was also closely related to unfavorable outcomes (aOR = 6.33, 95% CI: 1.15-34.79). In contrast, AF showed no significant association with END or unfavorable outcomes. Our data showed that patients with ICAS had larger and more severe initial stroke lesions, and poorer prognosis than those without.<h4>Conclusions</h4>ICAS, but not AF, was closely associated with poor prognosis in ischemic stroke patients with active cancer.
format article
author Ki-Woong Nam
Hyung-Min Kwon
Yong-Seok Lee
author_facet Ki-Woong Nam
Hyung-Min Kwon
Yong-Seok Lee
author_sort Ki-Woong Nam
title Effects of intracranial atherosclerosis and atrial fibrillation on the prognosis of ischemic stroke with active cancer.
title_short Effects of intracranial atherosclerosis and atrial fibrillation on the prognosis of ischemic stroke with active cancer.
title_full Effects of intracranial atherosclerosis and atrial fibrillation on the prognosis of ischemic stroke with active cancer.
title_fullStr Effects of intracranial atherosclerosis and atrial fibrillation on the prognosis of ischemic stroke with active cancer.
title_full_unstemmed Effects of intracranial atherosclerosis and atrial fibrillation on the prognosis of ischemic stroke with active cancer.
title_sort effects of intracranial atherosclerosis and atrial fibrillation on the prognosis of ischemic stroke with active cancer.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/23cae7ae55cf4d708e419aaab9464ac2
work_keys_str_mv AT kiwoongnam effectsofintracranialatherosclerosisandatrialfibrillationontheprognosisofischemicstrokewithactivecancer
AT hyungminkwon effectsofintracranialatherosclerosisandatrialfibrillationontheprognosisofischemicstrokewithactivecancer
AT yongseoklee effectsofintracranialatherosclerosisandatrialfibrillationontheprognosisofischemicstrokewithactivecancer
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