Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study

Abstract Objective Standardized investigation of epileptic seizures and the postictal state may contribute to a better understanding of ictal and postictal phenomena. This comparative case study aims to assess whether electrically induced seizures in electroconvulsive therapy (ECT) show sufficient s...

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Autores principales:	Julia C. M. Pottkämper, Joey P. A. J. Verdijk, Jeannette Hofmeijer, Jeroen A. vanWaarde, Michel J. A. M. vanPutten
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	alpha‐delta ratio electroencephalography ictal postictal time‐frequency analyses Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/23ccb172445a4f49878ac4374347dd42
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spelling	oai:doaj.org-article:23ccb172445a4f49878ac4374347dd422021-12-01T06:09:19ZSeizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study2470-923910.1002/epi4.12532https://doaj.org/article/23ccb172445a4f49878ac4374347dd422021-12-01T00:00:00Zhttps://doi.org/10.1002/epi4.12532https://doaj.org/toc/2470-9239Abstract Objective Standardized investigation of epileptic seizures and the postictal state may contribute to a better understanding of ictal and postictal phenomena. This comparative case study aims to assess whether electrically induced seizures in electroconvulsive therapy (ECT) show sufficient similarities with spontaneous seizures to serve as a human epilepsy model. Methods We compared six EEG recordings, three ECT‐induced seizures and three generalized tonic‐clonic seizures, using quantitative electroencephalography (EEG) analyses. EEG recordings during and after ECT sessions (under general anesthesia and muscle paralysis) were collected prospectively, whereas epilepsy data were selected retrospectively. Time‐frequency representations, dominant ictal frequencies, and postictal alpha‐delta ratios were calculated. Results In all EEG recordings, a decrease in dominant ictal frequency was observed, as well as postictal suppression. Postictal alpha‐delta ratio indicated the same trend for all: a gradual increase from predominantly delta to alpha frequencies on timescales of hours after the seizure. Postictal spectral representation was similar. Muscle artifacts were absent in ECT‐induced seizures and present in spontaneous seizures. Ictal amplitude was higher in epileptic than in ECT‐induced seizures. Temporospectral ictal dynamics varied slightly between groups. Significance We show that ictal and postictal characteristics in ECT and patients with generalized tonic‐clonic seizures are essentially similar. ECT‐induced seizures may be used to investigate aspects of ictal and postictal states in a highly predictable manner and well‐controlled environment. This suggests that clinical and electrophysiological observations during ECT may be extrapolated to epilepsy with generalized tonic‐clonic seizures.Julia C. M. PottkämperJoey P. A. J. VerdijkJeannette HofmeijerJeroen A. vanWaardeMichel J. A. M. vanPuttenWileyarticlealpha‐delta ratioelectroencephalographyictalpostictaltime‐frequency analysesNeurology. Diseases of the nervous systemRC346-429ENEpilepsia Open, Vol 6, Iss 4, Pp 672-684 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alpha‐delta ratio electroencephalography ictal postictal time‐frequency analyses Neurology. Diseases of the nervous system RC346-429
spellingShingle	alpha‐delta ratio electroencephalography ictal postictal time‐frequency analyses Neurology. Diseases of the nervous system RC346-429 Julia C. M. Pottkämper Joey P. A. J. Verdijk Jeannette Hofmeijer Jeroen A. vanWaarde Michel J. A. M. vanPutten Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study
description	Abstract Objective Standardized investigation of epileptic seizures and the postictal state may contribute to a better understanding of ictal and postictal phenomena. This comparative case study aims to assess whether electrically induced seizures in electroconvulsive therapy (ECT) show sufficient similarities with spontaneous seizures to serve as a human epilepsy model. Methods We compared six EEG recordings, three ECT‐induced seizures and three generalized tonic‐clonic seizures, using quantitative electroencephalography (EEG) analyses. EEG recordings during and after ECT sessions (under general anesthesia and muscle paralysis) were collected prospectively, whereas epilepsy data were selected retrospectively. Time‐frequency representations, dominant ictal frequencies, and postictal alpha‐delta ratios were calculated. Results In all EEG recordings, a decrease in dominant ictal frequency was observed, as well as postictal suppression. Postictal alpha‐delta ratio indicated the same trend for all: a gradual increase from predominantly delta to alpha frequencies on timescales of hours after the seizure. Postictal spectral representation was similar. Muscle artifacts were absent in ECT‐induced seizures and present in spontaneous seizures. Ictal amplitude was higher in epileptic than in ECT‐induced seizures. Temporospectral ictal dynamics varied slightly between groups. Significance We show that ictal and postictal characteristics in ECT and patients with generalized tonic‐clonic seizures are essentially similar. ECT‐induced seizures may be used to investigate aspects of ictal and postictal states in a highly predictable manner and well‐controlled environment. This suggests that clinical and electrophysiological observations during ECT may be extrapolated to epilepsy with generalized tonic‐clonic seizures.
format	article
author	Julia C. M. Pottkämper Joey P. A. J. Verdijk Jeannette Hofmeijer Jeroen A. vanWaarde Michel J. A. M. vanPutten
author_facet	Julia C. M. Pottkämper Joey P. A. J. Verdijk Jeannette Hofmeijer Jeroen A. vanWaarde Michel J. A. M. vanPutten
author_sort	Julia C. M. Pottkämper
title	Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study
title_short	Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study
title_full	Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study
title_fullStr	Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study
title_full_unstemmed	Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study
title_sort	seizures induced in electroconvulsive therapy as a human epilepsy model: a comparative case study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/23ccb172445a4f49878ac4374347dd42
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Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study

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