Assessment of macular function in patients with non-vascularized pigment epithelial detachment

Abstract Non-vascularized pigment epithelial detachments (PED) are usually associated with dry age-related macular degeneration (AMD). In this study, we aimed to investigate the correlation between visual function and morphologic parameters. Seventeen eyes of eleven patients with non-vascularized AM...

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Autores principales:	Marie Kitano, Asahi Fujita, Ryo Asaoka, Tatsuya Inoue, Tatsuaki Amari, Kayoko Komatsu, Motoshi Yamamoto, Asako Ogawa, Nobuyori Aoki, Masahiro Yamanari, Satoshi Sugiyama, Makoto Aihara, Satoshi Kato, Keiko Azuma, Maiko Maruyama-Inoue, Kazuaki Kadonosono, Ryo Obata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23cd7224a2d24ff687005f0b500edcdf
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spelling	oai:doaj.org-article:23cd7224a2d24ff687005f0b500edcdf2021-12-02T15:10:50ZAssessment of macular function in patients with non-vascularized pigment epithelial detachment10.1038/s41598-021-96151-82045-2322https://doaj.org/article/23cd7224a2d24ff687005f0b500edcdf2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96151-8https://doaj.org/toc/2045-2322Abstract Non-vascularized pigment epithelial detachments (PED) are usually associated with dry age-related macular degeneration (AMD). In this study, we aimed to investigate the correlation between visual function and morphologic parameters. Seventeen eyes of eleven patients with non-vascularized AMD were enrolled. In addition to conventional optical coherence tomography (OCT), polarization-sensitive optical coherence tomography (PS-OCT) measurements were performed by evaluating the regularity of retinal pigment epithelium (RPE) entropy within the PED area. Retinal sensitivity was measured with MP-3 microperimetry, and retinal sensitivities within (RSin) and outside (RSout) the PED area were calculated. The relationship between OCT parameters and visual function was analyzed. As a result, there was a significant difference between the RSin and RSout (p < 0.001, Wilcoxon signed rank test). Moreover, RSin was significantly related to logMAR VA (p = 0.033, linear mixed model). The regularity of RPE entropy was significantly related to visual acuity and RSin (p = 0.00038, p = 0.031, linear mixed model), although neither the height nor area of PED correlated with visual function. Our results suggest that retinal sensitivity is significantly deteriorated within the PED area and RPE entropy measured with PS-OCT was closely related to visual function in eyes with non-vascularized PED.Marie KitanoAsahi FujitaRyo AsaokaTatsuya InoueTatsuaki AmariKayoko KomatsuMotoshi YamamotoAsako OgawaNobuyori AokiMasahiro YamanariSatoshi SugiyamaMakoto AiharaSatoshi KatoKeiko AzumaMaiko Maruyama-InoueKazuaki KadonosonoRyo ObataNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie Kitano Asahi Fujita Ryo Asaoka Tatsuya Inoue Tatsuaki Amari Kayoko Komatsu Motoshi Yamamoto Asako Ogawa Nobuyori Aoki Masahiro Yamanari Satoshi Sugiyama Makoto Aihara Satoshi Kato Keiko Azuma Maiko Maruyama-Inoue Kazuaki Kadonosono Ryo Obata Assessment of macular function in patients with non-vascularized pigment epithelial detachment
description	Abstract Non-vascularized pigment epithelial detachments (PED) are usually associated with dry age-related macular degeneration (AMD). In this study, we aimed to investigate the correlation between visual function and morphologic parameters. Seventeen eyes of eleven patients with non-vascularized AMD were enrolled. In addition to conventional optical coherence tomography (OCT), polarization-sensitive optical coherence tomography (PS-OCT) measurements were performed by evaluating the regularity of retinal pigment epithelium (RPE) entropy within the PED area. Retinal sensitivity was measured with MP-3 microperimetry, and retinal sensitivities within (RSin) and outside (RSout) the PED area were calculated. The relationship between OCT parameters and visual function was analyzed. As a result, there was a significant difference between the RSin and RSout (p < 0.001, Wilcoxon signed rank test). Moreover, RSin was significantly related to logMAR VA (p = 0.033, linear mixed model). The regularity of RPE entropy was significantly related to visual acuity and RSin (p = 0.00038, p = 0.031, linear mixed model), although neither the height nor area of PED correlated with visual function. Our results suggest that retinal sensitivity is significantly deteriorated within the PED area and RPE entropy measured with PS-OCT was closely related to visual function in eyes with non-vascularized PED.
format	article
author	Marie Kitano Asahi Fujita Ryo Asaoka Tatsuya Inoue Tatsuaki Amari Kayoko Komatsu Motoshi Yamamoto Asako Ogawa Nobuyori Aoki Masahiro Yamanari Satoshi Sugiyama Makoto Aihara Satoshi Kato Keiko Azuma Maiko Maruyama-Inoue Kazuaki Kadonosono Ryo Obata
author_facet	Marie Kitano Asahi Fujita Ryo Asaoka Tatsuya Inoue Tatsuaki Amari Kayoko Komatsu Motoshi Yamamoto Asako Ogawa Nobuyori Aoki Masahiro Yamanari Satoshi Sugiyama Makoto Aihara Satoshi Kato Keiko Azuma Maiko Maruyama-Inoue Kazuaki Kadonosono Ryo Obata
author_sort	Marie Kitano
title	Assessment of macular function in patients with non-vascularized pigment epithelial detachment
title_short	Assessment of macular function in patients with non-vascularized pigment epithelial detachment
title_full	Assessment of macular function in patients with non-vascularized pigment epithelial detachment
title_fullStr	Assessment of macular function in patients with non-vascularized pigment epithelial detachment
title_full_unstemmed	Assessment of macular function in patients with non-vascularized pigment epithelial detachment
title_sort	assessment of macular function in patients with non-vascularized pigment epithelial detachment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23cd7224a2d24ff687005f0b500edcdf
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Assessment of macular function in patients with non-vascularized pigment epithelial detachment

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