Dyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia

Adnan Kemal,1,* Melese Sinaga Teshome,2,* Mohammed Ahmed,3 Meseret Molla,1 Tabarak Malik,4 Jemmal Mohammed,5 Kalkidan Hassen Abate2,* 1Department of Public Health, College of Health Science, Defense University, Addis Ababa, Ethiopia; 2Department of Nutrition and Dietetics, Jimma University, Jimma, E...

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Autores principales:	Kemal A, Teshome MS, Ahmed M, Molla M, Malik T, Mohammed J, Abate KH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	dyslipidemia hiv/aids antiretroviral therapy ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/23d23daa60e84443bf031ea62dc3ace0
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spelling	oai:doaj.org-article:23d23daa60e84443bf031ea62dc3ace02021-12-02T10:31:40ZDyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia1179-1373https://doaj.org/article/23d23daa60e84443bf031ea62dc3ace02020-07-01T00:00:00Zhttps://www.dovepress.com/dyslipidemia-and-associated-factors-among-adult-patients-on-antiretrov-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Adnan Kemal,1,* Melese Sinaga Teshome,2,* Mohammed Ahmed,3 Meseret Molla,1 Tabarak Malik,4 Jemmal Mohammed,5 Kalkidan Hassen Abate2,* 1Department of Public Health, College of Health Science, Defense University, Addis Ababa, Ethiopia; 2Department of Nutrition and Dietetics, Jimma University, Jimma, Ethiopia; 3Department of Public Health, College of Health Science, Woldia University, Woldia, Ethiopia; 4Department of Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 5Department of Ophthalmology, Jimma University, Jimma, Ethiopia*These authors contributed equally to this workCorrespondence: Melese Sinaga Teshome; Adnan Kemal Email sinmele@gmail.com; adnankemale@gmail.comBackground: The development of antiretroviral drugs and subsequent access to combined antiretroviral therapy contributed to the decline in morbidity and mortality rates associated with acquired immune deficiency syndrome, resulting in an increased life expectancy and improved quality of life for people living with human immunodeficiency virus. However, a cluster of metabolic derangements such as dyslipidemia is increasing, especially for those on antiretroviral therapy. Limited studies were done on the prevalence of dyslipidemia and its associated factors among adult patients on antiretroviral therapy in Ethiopia which demand the conduct of the present investigation entitled on the prevalence of dyslipidemia and its associated factors among adult patients on antiretroviral therapy in Armed Force Comprehensive and Specialized Hospital Addis Ababa, Ethiopia, 2018.Methods: Institution-based cross-sectional study design was employed between March and April 2018. Systematic sampling method was used to select 353 study participants. Pretested stepwise approach of the World Health Organization questionnaire (WHO Stepwise), document review, anthropometric measurements, and laboratory analysis were used to collect data on different variables under the study. Collected data were entered in Epidata version 3 and analyzed by SPSS version 21.Results: The prevalence of dyslipidemia among study participants was 74.8%. Female participants were twice and half at risk of developing dyslipidemia compared to males (AOR= 2.38; 95% CI: 1.15, 3.66). Similarly, compared to those attended college level of education, not attended formal education (AOR=0.19; 95% CI: 0.05, 0.66), and having primary/secondary educational level (AOR= 0.33; 95% CI: 0.16, 0.66) showed lower odds to develop dyslipidemia. Furthermore, WHO clinical stage II (AOR= 0.35; 95% CI: 0.14,0.92), stage III (AOR=0.25; 95% CI:0.10,0.64), duration on ART (AOR= 1.01; 95% CI: 1.001,1.02), and BMI (AOR =1.13; 95% CI: 1.06,1.23) were significantly associated with dyslipidemia.Conclusion: There exists a high prevalence of dyslipidemia among study participants. Sex, educational status, WHO clinical stage, duration on ART, and BMI were significantly associated factors for dyslipidemia. Intervention strategies including the identified factors are demanded in the setting.Keywords: dyslipidemia, HIV/AIDS, antiretroviral therapy, EthiopiaKemal ATeshome MSAhmed MMolla MMalik TMohammed JAbate KHDove Medical Pressarticledyslipidemiahiv/aidsantiretroviral therapyethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 221-231 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	dyslipidemia hiv/aids antiretroviral therapy ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	dyslipidemia hiv/aids antiretroviral therapy ethiopia Immunologic diseases. Allergy RC581-607 Kemal A Teshome MS Ahmed M Molla M Malik T Mohammed J Abate KH Dyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia
description	Adnan Kemal,1,* Melese Sinaga Teshome,2,* Mohammed Ahmed,3 Meseret Molla,1 Tabarak Malik,4 Jemmal Mohammed,5 Kalkidan Hassen Abate2,* 1Department of Public Health, College of Health Science, Defense University, Addis Ababa, Ethiopia; 2Department of Nutrition and Dietetics, Jimma University, Jimma, Ethiopia; 3Department of Public Health, College of Health Science, Woldia University, Woldia, Ethiopia; 4Department of Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 5Department of Ophthalmology, Jimma University, Jimma, Ethiopia*These authors contributed equally to this workCorrespondence: Melese Sinaga Teshome; Adnan Kemal Email sinmele@gmail.com; adnankemale@gmail.comBackground: The development of antiretroviral drugs and subsequent access to combined antiretroviral therapy contributed to the decline in morbidity and mortality rates associated with acquired immune deficiency syndrome, resulting in an increased life expectancy and improved quality of life for people living with human immunodeficiency virus. However, a cluster of metabolic derangements such as dyslipidemia is increasing, especially for those on antiretroviral therapy. Limited studies were done on the prevalence of dyslipidemia and its associated factors among adult patients on antiretroviral therapy in Ethiopia which demand the conduct of the present investigation entitled on the prevalence of dyslipidemia and its associated factors among adult patients on antiretroviral therapy in Armed Force Comprehensive and Specialized Hospital Addis Ababa, Ethiopia, 2018.Methods: Institution-based cross-sectional study design was employed between March and April 2018. Systematic sampling method was used to select 353 study participants. Pretested stepwise approach of the World Health Organization questionnaire (WHO Stepwise), document review, anthropometric measurements, and laboratory analysis were used to collect data on different variables under the study. Collected data were entered in Epidata version 3 and analyzed by SPSS version 21.Results: The prevalence of dyslipidemia among study participants was 74.8%. Female participants were twice and half at risk of developing dyslipidemia compared to males (AOR= 2.38; 95% CI: 1.15, 3.66). Similarly, compared to those attended college level of education, not attended formal education (AOR=0.19; 95% CI: 0.05, 0.66), and having primary/secondary educational level (AOR= 0.33; 95% CI: 0.16, 0.66) showed lower odds to develop dyslipidemia. Furthermore, WHO clinical stage II (AOR= 0.35; 95% CI: 0.14,0.92), stage III (AOR=0.25; 95% CI:0.10,0.64), duration on ART (AOR= 1.01; 95% CI: 1.001,1.02), and BMI (AOR =1.13; 95% CI: 1.06,1.23) were significantly associated with dyslipidemia.Conclusion: There exists a high prevalence of dyslipidemia among study participants. Sex, educational status, WHO clinical stage, duration on ART, and BMI were significantly associated factors for dyslipidemia. Intervention strategies including the identified factors are demanded in the setting.Keywords: dyslipidemia, HIV/AIDS, antiretroviral therapy, Ethiopia
format	article
author	Kemal A Teshome MS Ahmed M Molla M Malik T Mohammed J Abate KH
author_facet	Kemal A Teshome MS Ahmed M Molla M Malik T Mohammed J Abate KH
author_sort	Kemal A
title	Dyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia
title_short	Dyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia
title_full	Dyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia
title_fullStr	Dyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia
title_full_unstemmed	Dyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia
title_sort	dyslipidemia and associated factors among adult patients on antiretroviral therapy in armed force comprehensive and specialized hospital, addis ababa, ethiopia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/23d23daa60e84443bf031ea62dc3ace0
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Dyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia

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