Promotion of growth factor signaling as a critical function of β-catenin during HCC progression

Aberrant Wnt/b-catenin signaling is thought to be a major driver of hepatocellular carcinoma. Here, the authors show that β-Catenin is predominantly integrated within the AJ complex during the early stages of this cancer and enhance EGFR signaling to promote tumour survival.

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Autores principales:	Eunsun Kim, Amanda Lisby, Connie Ma, Nathanael Lo, Ursula Ehmer, Katharina E. Hayer, Emma E. Furth, Patrick Viatour
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23d83511c5b14bb7b618f8c1a6766131
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spelling	oai:doaj.org-article:23d83511c5b14bb7b618f8c1a67661312021-12-02T16:58:28ZPromotion of growth factor signaling as a critical function of β-catenin during HCC progression10.1038/s41467-019-09780-z2041-1723https://doaj.org/article/23d83511c5b14bb7b618f8c1a67661312019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09780-zhttps://doaj.org/toc/2041-1723Aberrant Wnt/b-catenin signaling is thought to be a major driver of hepatocellular carcinoma. Here, the authors show that β-Catenin is predominantly integrated within the AJ complex during the early stages of this cancer and enhance EGFR signaling to promote tumour survival.Eunsun KimAmanda LisbyConnie MaNathanael LoUrsula EhmerKatharina E. HayerEmma E. FurthPatrick ViatourNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eunsun Kim Amanda Lisby Connie Ma Nathanael Lo Ursula Ehmer Katharina E. Hayer Emma E. Furth Patrick Viatour Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
description	Aberrant Wnt/b-catenin signaling is thought to be a major driver of hepatocellular carcinoma. Here, the authors show that β-Catenin is predominantly integrated within the AJ complex during the early stages of this cancer and enhance EGFR signaling to promote tumour survival.
format	article
author	Eunsun Kim Amanda Lisby Connie Ma Nathanael Lo Ursula Ehmer Katharina E. Hayer Emma E. Furth Patrick Viatour
author_facet	Eunsun Kim Amanda Lisby Connie Ma Nathanael Lo Ursula Ehmer Katharina E. Hayer Emma E. Furth Patrick Viatour
author_sort	Eunsun Kim
title	Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
title_short	Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
title_full	Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
title_fullStr	Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
title_full_unstemmed	Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
title_sort	promotion of growth factor signaling as a critical function of β-catenin during hcc progression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/23d83511c5b14bb7b618f8c1a6766131
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Promotion of growth factor signaling as a critical function of β-catenin during HCC progression

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