Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons

Abstract Stress responses are highly plastic and vary across physiological states. The female estrous cycle is associated with a number of physiological changes including changes in stress responses, however, the mechanisms driving these changes are poorly understood. Corticotropin-releasing hormone...

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Autores principales:	Emmet M. Power, Karl J. Iremonger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23d8e715593244bf952369f6b1c31a23
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spelling	oai:doaj.org-article:23d8e715593244bf952369f6b1c31a232021-12-02T17:08:37ZPlasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons10.1038/s41598-021-96341-42045-2322https://doaj.org/article/23d8e715593244bf952369f6b1c31a232021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96341-4https://doaj.org/toc/2045-2322Abstract Stress responses are highly plastic and vary across physiological states. The female estrous cycle is associated with a number of physiological changes including changes in stress responses, however, the mechanisms driving these changes are poorly understood. Corticotropin-releasing hormone (CRH) neurons are the primary neural population controlling the hypothalamic–pituitary–adrenal (HPA) axis and stress-evoked corticosterone secretion. Here we show that CRH neuron intrinsic excitability is regulated over the estrous cycle with a peak in proestrus and a nadir in estrus. Fast inactivating voltage-gated potassium channel (IA) currents showed the opposite relationship, with current density being lowest in proestrus compared to other cycle stages. Blocking IA currents equalized excitability across cycle stages revealing a role for IA in mediating plasticity in stress circuit function over the female estrous cycle.Emmet M. PowerKarl J. IremongerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emmet M. Power Karl J. Iremonger Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons
description	Abstract Stress responses are highly plastic and vary across physiological states. The female estrous cycle is associated with a number of physiological changes including changes in stress responses, however, the mechanisms driving these changes are poorly understood. Corticotropin-releasing hormone (CRH) neurons are the primary neural population controlling the hypothalamic–pituitary–adrenal (HPA) axis and stress-evoked corticosterone secretion. Here we show that CRH neuron intrinsic excitability is regulated over the estrous cycle with a peak in proestrus and a nadir in estrus. Fast inactivating voltage-gated potassium channel (IA) currents showed the opposite relationship, with current density being lowest in proestrus compared to other cycle stages. Blocking IA currents equalized excitability across cycle stages revealing a role for IA in mediating plasticity in stress circuit function over the female estrous cycle.
format	article
author	Emmet M. Power Karl J. Iremonger
author_facet	Emmet M. Power Karl J. Iremonger
author_sort	Emmet M. Power
title	Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons
title_short	Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons
title_full	Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons
title_fullStr	Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons
title_full_unstemmed	Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons
title_sort	plasticity of intrinsic excitability across the estrous cycle in hypothalamic crh neurons
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23d8e715593244bf952369f6b1c31a23
work_keys_str_mv	AT emmetmpower plasticityofintrinsicexcitabilityacrosstheestrouscycleinhypothalamiccrhneurons AT karljiremonger plasticityofintrinsicexcitabilityacrosstheestrouscycleinhypothalamiccrhneurons
_version_	1718381543220576256

Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons

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